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Your Position: ホーム > IL-7 R alpha

IL-7 R alpha

概要

Name:Interleukin-7 receptor subunit alpha
Target Synonym:Interleukin-7 receptor subunit alpha,Interleukin 7 Receptor Isoform H5-6,CDw127,IL-7R subunit alpha,IL-7RA,IL-7 receptor subunit alpha,CD127 Antigen,IL-7R-Alpha,Interleukin 7 Receptor Alpha Chain,CD127,IL7RA,ILRA,Interleukin-7 Receptor alpha Subunit
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:9
Lastest Research Phase:Phase 2 Clinical

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製造番号 種類 製品説明 構造 純度 特徴
IL7-H52H7 Human Human IL-7 R alpha / CD127 Protein, His Tag
IL7-H52H7-structure
IL7-H52H7-sds
IL7-H82F9 Human Biotinylated Human IL-7 R alpha / CD127 Protein, Fc,Avitag™
IL7-H82F9-structure
IL7-H82F9-sds
ILR-M5253 Mouse Mouse IL-7 R alpha / CD127 Protein, Fc Tag
ILR-M5253-structure
ILR-M5253-sds
ILA-H525a Human Human IL-7 R alpha / CD127 Protein, Fc Tag
ILA-H525a-structure
ILA-H525a-sds
IL7-H5258 Human Human IL-7 R alpha / CD127 Protein (I66T, V138I), Mouse IgG2a Fc Tag
IL7-H5258-structure
IL7-H5258-sds
ACRO Quality

生物活性データの一部

IL7-H5258-SPR
IL-7 R alpha SPR

Captured Human IL-7 R alpha, Mouse IgG2a Fc Tag (Cat. No. IL7-H5258) on CM5 chip via anti-mouse antibodies surface can bind ActiveMax® Human IL-7, Tag Free (Cat. No. IL7-H4219) with an affinity constant of 13.3 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol
IL7-H82F9-ELISA
IL-7 R alpha ELISA

Immobilized Human IL-7, Fc Tag (Cat. No. IL7-H5253) at 2 μg/mL (100 μL/well) can bind Biotinylated Human IL-7 R alpha Protein, Fc,Avitag (Cat. No. IL7-H82F9) with a linear range of 1-20 ng/mL (QC tested).

Protocol

Synonym Name

IL7Ra,CD127

Background

Interleukin-7 receptor subunit alpha (IL7Ra) is also known as CD antigen CD127, which belongs to the type I cytokine receptor family and type 4 subfamily. IL7Ra /CD127 contains 1 fibronectin type-III domain. IL7Ra /CD127 is expressed on various cell types, including naive and memory T cells and many others. IL7Ra /CD127 is receptor for interleukin-7 and also acts as a receptor for thymic stromal lymphopoietin (TSLP). The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.

Clinical and Translational Updates

相関分子

IL-7

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
PF-06342674 RN-168; PF-6342674; PF-06342674 Pfizer Inc Details
MDK-703 MDK-703 Phase 1 Clinical Medikine Inc Details
ASP-9801 ASP-9801 Phase 1 Clinical Astellas Pharma Inc Solid tumours; Neoplasms; Neoplasm Metastasis Details
Lusvertikimab OSE-127; S-95011 Phase 2 Clinical Effimune Sjogren's Syndrome; Colitis, Ulcerative Details
Interleukin-7 (Revimmune SAS) rhIL-7; CYT-107; CYT-99-007 Phase 2 Clinical Cytheris Urinary Bladder Neoplasms; Neuroectodermal Tumors, Primitive, Peripheral; Melanoma; Catheter-Related Infections; T-Lymphocytopenia, Idiopathic CD4-Positive; Leukemia, Myeloid, Acute; Hepatitis C; Ureteral Neoplasms; Urologic Neoplasms; Lymphopenia; Neuroblastoma; Sarcoma; Urethral Neoplasms; Prostatic Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Carcinoma, Transitional Cell; Coronavirus Disease 2019 (COVID-19); Mycobacterium Infections, Nontuberculous; Sepsis; Myeloproliferative Disorders; Myelodysplastic Syndromes; Hepatitis B, Chronic; Carcinoma, Renal Cell; Rhabdoid Tumor; Shock, Septic; Kidney Neoplasms; HIV Infections Details
Efineptakin alfa NT-I7; GX-I7; TJ-107 Phase 2 Clinical Genexine Inc Pancreatic Neoplasms; Carcinoma, Non-Small-Cell Lung; Melanoma; Sarcoma, Kaposi; Carcinoma, Squamous Cell; Leukoencephalopathy, Progressive Multifocal; Gliosarcoma; Astrocytoma; Lymphopenia; Colorectal Neoplasms; Breast Neoplasms; Urinary Bladder Neoplasms; HIV Infections; Triple Negative Breast Neoplasms; Small Cell Lung Carcinoma; Coronavirus Disease 2019 (COVID-19); Papillomavirus Infections; Glioblastoma; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Merkel Cell; Esophageal Neoplasms; Solid tumours; Ovarian Neoplasms Details

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