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TL1A

概要

Name:Tumor necrosis factor superfamily member 15
Target Synonym:VEGI192A,Vascular Endothelial Cell Growth Inhibitor,TNF Superfamily Ligand TL1A,TNFSF15,Tumor Necrosis Factor (Ligand) Superfamily, Member 15,Vascular Endothelial Growth Inhibitor-192A,VEGI,TL1A,Tumor Necrosis Factor Ligand 1B,TNLG1B,TNF Superfamily Member 15,Tumor Necrosis Factor Superfamily Member 15,TL1,TNF Ligand-Related Molecule 1,Tumor Necrosis Factor Ligand Superfamily Member 15,MGC129934,MGC129935
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:11
Lastest Research Phase:Phase 3 Clinical

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製造番号 種類 製品説明 構造 純度 特徴
SCRAJ-STT204 Human Raji/Membrane-Bound Human TL1A Stable Cell Line
CHEK-ATP198 Human HEK293/Membrane-Bound human TL1A Stable Cell Line
TLA-H5263 Human Human TL1A / TNFSF15 Protein, Fc Tag, active trimer (MALS verified)
TLA-H5263-sds
TLA-H5246 Human Human TL1A / TNFSF15 Protein, His Tag (Monomer) (MALS verified)
TLA-H5246-structure
TLA-H5246-sds
CHEK-ATP142 Human HEK293/Human TL1A Stable Cell Line
TLA-R5249 Rat Rat TL1A Protein, His Tag
TLA-R5249-structure
TLA-R5249-sds
TLA-H5245 Human Human TL1A / TNFSF15 Protein, His Tag
TLA-H5245-structure
TLA-H5245-sds
TLA-M5243 Mouse Mouse TL1A Protein, His Tag (HPLC-verified)
TLA-M5243-structure
TLA-M5243-sds
TLA-M5243-hplc
TLA-H5244 Human Human TL1A / TNFSF15 Protein, His Tag (MALS verified)
TLA-H5244-structure
TLA-H5244-sds
TLA-H52Q1 Human Biotinylated Human TL1A / TNFSF15 Protein, His,Avitag™
TLA-H52Q1-structure
TLA-H52Q1-sds
TLA-C5241 Cynomolgus / Rhesus macaque Cynomolgus/Rhesus macaque TL1A / TNFSF15 Protein, His Tag (MALS verified)
TLA-C5241-structure
TLA-C5241-sds
TLA-H5243 Human Human TL1A / TNFSF15 Protein, His Tag, active trimer (MALS verified)
TLA-H5243-structure
TLA-H5243-sds
ACRO Quality

生物活性データの一部

SCRAJ-STT204-Cell-based assay
TL1A FACS

Expression analysis of human TL1A on Raji/Membrane-Bound Human TL1A Stable Cell Line by FACS.
Cell surface staining was performed on Raji/Membrane-Bound Human TL1A Stable Cell Line or negative control cell using anti-human TL1A antibody followed by staining with PE anti-human IgG Fc antibody.

Protocol
CHEK-ATP198-Cell-based assay
TL1A FACS

Expression analysis of human TL1A on HEK293/Membrane-Bound Human TL1A Stable Cell Line by FACS.
Cell surface staining was performed on HEK293/Membrane-Bound Human TL1A Stable Cell Line or negative control cell using anti-human TL1A antibody followed by staining with PE anti-human IgG Fc antibody.

Protocol
TLA-H5263-SPR
TL1A SPR

Human TL1A Protein, Fc Tag (Cat. No. TLA-H5263) immobilized on CM5 Chip can bind Human DcR3, Fc Tag (Cat. No. TNB-H5255) with an affinity constant of 0.621 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
TLA-H5263-SPR
TL1A SPR

Human TL1A Protein, Fc Tag (Cat. No. TLA-H5263) immobilized on CM5 Chip can bind Human DR3 Protein, His Tag (Cat. No. TN5-H52H3) with an affinity constant of 1.05 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol

Synonym Name

TL1A, VEGI-251, TNFSF15

Background

TNF-like cytokine 1A (TL1A) and its receptors, death receptor 3 (DR3) and decoy receptor 3 (DcR3) are members of the TNF and TNF receptor superfamilies of proteins, respectively. Binding of APC-derived TL1A to lymphocytic DR3 provides co-stimulatory signals for activated lymphocytes. DR3 signaling affects not only the proliferative activity of and cytokine production by effector lymphocytes, but also critically influences the development and suppressive function of regulatory T-cells. Whereas, DcR3 restricts the function of the TL1A/DR3 complex: attenuating T-cell activation and downregulating the secretion of pro-inflammatory cytokines. Together with DR3 and DcR3, TL1A constitutes a cytokine system that actively interferes with the regulation of immune responses.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
PRA-023 PRA-023 Phase 2 Clinical Prometheus Biosciences Inc Inflammatory Bowel Diseases; Lung Diseases, Interstitial; Colitis, Ulcerative; Scleroderma, Diffuse; Crohn Disease Details
PF-06480605 PF-06480605 Phase 2 Clinical Pfizer Pharmaceuticals Ltd (China) Inflammatory Bowel Diseases; Colitis, Ulcerative; Crohn Disease Details

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