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DLL3

概要

Name:Delta-like protein 3
Target Synonym:Delta-Like Protein 3,Delta3,Delta-Like 3,Drosophila Delta Homolog 3,SCDO1,Delta-Like 3 (Drosophila),DLL3,Delta (Drosophila)-Like 3,Delta Like Canonical Notch Ligand 3
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:13
Lastest Research Phase:NDA/BLA

Antibody Licensing

Project Name Project Stage Molecule Type Host Species Therapeutic Area Indications
DLL3 mAb - 01 Lead Solid Tumor Small cell lung cancer

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製造番号 種類 製品説明 構造 純度 特徴
MBS-C018 Human ActiveMax® Human DLL3 μBeads, premium grade (for cells)
SCCHO-ATP111 Human CHO/Human DLL3 Stable Cell Line Development Service
DL3-HA2H3 Human Alexa Fluor™ 647-Labeled Human DLL3 Protein, His TagStar Staining
DL3-HA2H8 Human APC-Labeled Human DLL3 Protein, His TagStar Staining
CHEK-ATP090 Human HEK293/Human DLL3 Stable Cell Line
DL3-HP2H7 Human PE-Labeled Human DLL3 Protein, His Tag (Site-specific conjugation)
DL3-HP2H7-structure
DL3-H525x Human Human DLL3 Protein, Llama IgG2b Fc Tag
DL3-H525x-structure
DL3-H525x-sds
DL3-C82E9 Cynomolgus Biotinylated Cynomolgus DLL3 Protein, His,Avitag™
DL3-C82E9-structure
DL3-C82E9-sds
DL3-C52H9 Cynomolgus Cynomolgus DLL3 (27-488) Protein, His Tag
DL3-C52H9-structure
DL3-C52H9-sds
DL3-M52H9 Mouse Mouse DLL3 Protein, His Tag
DL3-M52H9-sds
DL3-H52Hy Human Human DLL3 (176-492) Protein, His Tag
DL3-H52Hy-structure
DL3-H52Hy-sds
DL3-H52Hz Human Human DLL3 (312-492) Protein, His Tag
DL3-H52Hz-structure
DL3-H52Hz-sds
DL3-H52Ha Human Human DLL3 (353-492) Protein, His Tag
DL3-H52Ha-structure
DL3-H52Ha-sds
DL3-H82E4 Human Biotinylated Human DLL3 Protein, His,Avitag™ (MALS verified)
DL3-H82E4-structure
DL3-H82E4-sds
DL3-R52H4 Rhesus macaque Rhesus macaque DLL3 Protein, His Tag
DL3-R52H4-structure
DL3-R52H4-sds
DL3-R52H3 Rat Rat DLL3 Protein, His Tag
DL3-R52H3-structure
DL3-R52H3-sds
DL3-HF2H4 Human FITC-Labeled Human DLL3 Protein, His Tag
DL3-HF2H4-structure
DL3-HF2H4-sds
DL3-C52H3 Cynomolgus Cynomolgus DLL3 Protein, His Tag
DL3-C52H3-structure
DL3-C52H3-sds
DL3-H52H4 Human Human DLL3 Protein, His Tag (MALS verified)
DL3-H52H4-structure
DL3-H52H4-sds
ACRO Quality

生物活性データの一部

DL3-HA2H3-Cell-based assay
DLL3 CAR_T

5e5 of anti-DLL3 CAR-293 cells were stained with 100 μL of 1 μg/mL of Alexa Fluor 647-Labeled Human DLL3 Protein, His Tag (Cat. No. DL3-HA2H3) and negative control protein respectively (Fig. C and B), and non-transfected 293 cells were used as a control (Fig. A). Alexa 647 signal was used to evaluate the binding activity (QC tested).

Protocol
DL3-C52H9-SPR
DLL3 SPR

Bispecific T-cell Engager captured on Protein A Chip can bind Cynomolgus DLL3 (27-488), His Tag (Cat. No. DL3-C52H9) with an affinity constant of 1.02 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
DL3-M52H9-SPR
DLL3 SPR

Bispecific T-cell Engager captured on Protein A Chip can bind Mouse DLL3, His Tag (Cat. No. DL3-M52H9) with an affinity constant of 1.13 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol

Synonym Name

Delta3,delta-like 3 (Drosophila),delta-like protein 3,DLL3,Pudgy,SCDO1,SCDO1delta3

Background

Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands.May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 protein is expressed on the surface of tumor cells but not in normal adult tissues.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
89Zr-DFO-SC16.56 89Zr-DFO-SC16.56 Phase 1 Clinical Memorial Sloan Kettering Cancer Center Small Cell Lung Carcinoma Details
AMG-119 AMG-119 Amgen Inc Details
HPN-328 HPN-328 Harpoon Therapeutics Details
QLS-31904 QLS31904; QLS-31904 Phase 1 Clinical Qilu Pharmaceutical Co Ltd Solid tumours Details
DLL3-CAR-NK cells Therapy(Tianjin Medical University Cancer Institute and Hospital) DLL3-CAR-NK cells Phase 1 Clinical Tianjin Medical University Cancer Institute And Hospital Small Cell Lung Carcinoma Details
PT-217 PT-217 Phase 1 Clinical Phanes Therapeutics Inc Small Cell Lung Carcinoma; Carcinoma, Neuroendocrine Details
BI-764532 BI-764532 Phase 1 Clinical C.H. Boehringer Sohn Ag & Co. Kg Small Cell Lung Carcinoma; Neoplasms Details
OBT620 OBT620 Phase 1 Clinical Boehringer Ingelheim Gmbh, Oxford Biotherapeutics Ltd Small Cell Lung Carcinoma Details
Tarlatamab AMG-757 Phase 2 Clinical Amgen Inc Small Cell Lung Carcinoma; Prostatic Neoplasms Details
LB-2102(Legend Biotechnology) LB-2102 Phase 1 Clinical Nanjing Legend Biotechnology Co Ltd Small Cell Lung Carcinoma Details
Rovalpituzumab tesirine SC-0002; SC0001SCX; SC16LD6.5; SC0001-SCX; P256HB60FF Phase 1 Clinical Stemcentrx Inc, Abbvie Inc Solid tumours; Small Cell Lung Carcinoma; Glioblastoma; Neoplasms; Prostatic Neoplasms; Medullary thyroid cancer (MTC); Carcinoma, Neuroendocrine; Melanoma Details

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