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TREM2

概要

Name:Triggering receptor expressed on myeloid cells 2
Target Synonym:TREM-2,Triggering receptor expressed on monocytes 2,PLOSL2,Trem2b,Trem2a,Trem2c,Triggering Receptor Expressed On Myeloid Cells 2a
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 2 Clinical

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生物活性データの一部

TR2-H52H5-SPR
 TREM2 SPR

Anti-TREM2 antibody captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human TREM2, His Tag (Cat. No. TR2-H52H5) with an affinity constant of 95.9 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

TR2-H5254-BLI
 TREM2 BLI

Loaded Human TREM2, Fc Tag (Cat. No. TR2-H5254) on Protein A Biosensor, can bind Human APOE3, His Tag (Cat. No. APE-H5246) with an affinity constant of 66.1 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

Triggering receptor expressed on myeloid cells 2,TREM2,TREM-2

Background

Triggering receptor expressed on myeloid cells 2 (TREM2) is a cell surface receptor of the immunoglobulin superfamily. The TREM2 is found in various tissue macrophages, such as CNS microglia, bone osteoclasts, alveolar, peritoneal and intestinal macrophages. TREM2 is also present on cultured bone marrow-derived macrophages and monocyte-derived dendritic cells. Some research have identified a rare variant of TREM2 that is a risk factor for Alzheimer disease (AD), which is the most common form of late-onset dementia.The extracellular region of TREM2 contains a single immunoglobulin superfamily domain and binds polyanionic ligands, such as bacterial lipopolysaccharide (LPS) and phospholipids8. Upon ligand binding, TREM2 transmits intracellular signals through an adaptor, DAP12 (also known as TYRO protein tyrosine kinase-binding protein (TYROBP)), which is associated with the transmembrane region of TREM2 and which recruits the protein tyrosine kinase SYK through its cytosolic immunoreceptor tyrosine-based activation motifs (ITAMs). TREM2 is a pro-tumorigenic marker of tumor-infiltrating macrophages in mouse models and human tumors that can be targeted to curb tumor growth and improve the efficacy of checkpoint blockade therapy while remodeling the landscape of tumor-infiltrating macrophages.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
PY-314 PY-314; PY314 Phase 1 Clinical Gilead Sciences Inc Solid tumours; Ovarian Neoplasms; Carcinoma, Renal Cell; Adenocarcinoma of Lung; Triple Negative Breast Neoplasms; Breast Neoplasms; Genital Neoplasms, Female; Colorectal Neoplasms Details
DNL-919 DNL-919 Phase 1 Clinical Denali Therapeutics Inc Alzheimer Disease Details
AL-002 AL-002a; AL-002-a; AL-002 Phase 2 Clinical Abbvie Inc, Alector Alzheimer Disease Details

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