ログイン 会員登録
icon_bulk_order一括注文 Acrobiosystems for English
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
phone
Your Position: ホーム > Protein > Fc gamma RIIB / CD32b > CDB-C5224

Cynomolgus Fc gamma RIIB / CD32b Protein, His Tag (MALS & SPR verified)

  • シノニム
  • ソース
    Cynomolgus CD32b, His Tag (CDB-C5224) is expressed from human 293 cells (HEK293). It contains AA Ala 46 - Pro 224 (Accession # Q8SPW3-1).
    Predicted N-terminus: Ala 46
  • 分子特性
    Online(Ala 46 - Pro 224) Q8SPW3-1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 21.8 kDa. The protein migrates as 30-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • エンドトキシン
    Less than 1.0 EU per μg by the LAL method.
  • 純度

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • 成分

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • 再構成

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 保存

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 12 months under sterile conditions after reconstitution.
SDS-PAGE
Cynomolgus CD32b, His Tag (Cat. No. CDB-C5224) SDS-PAGE gel

Cynomolgus CD32b, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

SEC-MALS
Cynomolgus CD32b, His Tag (Cat. No. ) MALS images

The purity of Cynomolgus CD32b, His Tag (Cat. No. CDB-C5224) is more than 90% and the molecular weight of this protein is around 20-30 kDa verified by SEC-MALS.

Bioactivity-SPR
Human_FcRn_Heterodimer_Protein_SPR

Cynomolgus CD32b, His Tag (Cat. No. CDB-C5224) captured on CM5 chip via anti-His antibody can Herceptin® with an affinity constant of 11.9 μM as determined in a SPR assay (Biacore T200) (QC tested).

  • バックグラウンド
    Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

コメント (0)


ETD of in-stock products: 4 business days

価格(JPY) : 61,600

価格(JPY) : 84,000

価格(JPY) : 610,400

プロモーション&展示



医薬品開発状況

  • Number of Launched Drugs:0 Details
  • Number of Drugs in Clinical Trials:5 Details
  • Latest Research Phase:Phase 3 Clinical

データシート&ドキュメンテーション

DMF請求
DMF (Drug Master File)

関連製品一覧

新製品

お問い合わせ&コメント

This web search service is supported by Google Inc.

totopphone