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Your Position: ホーム > Siglec-15

Siglec-15

概要

Name:Sialic acid-binding Ig-like lectin 15
Target Synonym:SIGLEC15,Sialic Acid Binding Ig Like Lectin 15,CD33 Antigen-Like 3,CD33L3,Sialic Acid-Binding Ig-Like Lectin 15,SIGLEC-15,HsT1361,CD33 Molecule-Like 3,Sialic Acid Binding Ig-Like Lectin 15
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 2 Clinical

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製造番号 種類 製品説明 構造 純度 特徴
SG5-H5254 Human Human Siglec-15 / CD33L3 Protein, Mouse IgG2a Fc Tag (MALS verified)
SG5-H5254-structure
SG5-H5254-sds
SG5-C5253 Rhesus macaque Rhesus macaque Siglec-15 / CD33L3 Protein, Fc Tag
SG5-C5253-structure
SG5-C5253-sds
SG5-H82F5 Human Biotinylated Human Siglec-15 / CD33L3 Protein, Fc,Avitag™
SG5-H82F5-structure
SG5-H82F5-sds
SG5-H82E9 Human Biotinylated Human Siglec-15 / CD33L3 Protein, His,Avitag™ (recommended for biopanning)
SG5-H82E9-structure
SG5-H82E9-sds
SG5-M52H7 Mouse Mouse Siglec-15 / CD33L3 Protein, His Tag
SG5-M52H7-structure
SG5-M52H7-sds
SG5-C52H6 Rhesus macaque Rhesus macaque Siglec-15 / CD33L3 Protein, His Tag
SG5-C52H6-structure
SG5-C52H6-sds
SG5-H5253 Human Human Siglec-15 / CD33L3 Protein, Fc Tag
SG5-H5253-structure
SG5-H5253-sds
SG5-H52H3 Human Human Siglec-15 / CD33L3 Protein, His Tag (MALS verified)
SG5-H52H3-structure
SG5-H52H3-sds
ACRO Quality

生物活性データの一部

SG5-H82F5-Cell-based assay
Siglec-15 CELL

Biotinylated Human Siglec-15, Fc,Avitag (Cat. No. SG5-H82F5) inhibits Anti-CD3-induced proliferation of PBMC. The ED50 for this effect is 0.48-0.57 μg/mL (Routinely tested).

Protocol
SG5-H5253-Cell-based assay
Siglec-15 CELL

Human Siglec-15, Fc Tag (Cat. No. SG5-H5253) inhibits Anti-CD3-induced proliferation of PBMC. The ED50 for this effect is 0.46-0.54 μg/mL (Routinely tested).

Protocol
SG5-H5253-SPR
Siglec-15 SPR

Immobilized Neu5Ac(a2-6)GalNAc-PAA-biotin on SA Chip can bind Human Siglec-15, Fc Tag (Cat. No. SG5-H5253) with an affinity constant of 4.49 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol
SG5-C5253-BLI
Siglec-15 BLI

Loaded Rhesus macaque Siglec-15 Protein, Fc Tag (Cat. No. SG5-C5253) on ProteinA Biosensor, can bind Neu5Ac(a2-6)GalNAc-PAA-biotin with an affinity constant of 0.62 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

カスタマーレビュー

Synonym Name

CD33 antigen-like 3,SIGLEC-15,CD33L3,sialic acid-binding Ig-like lectin 15,Siglec15,Siglec-15

Background

Siglec-15 is a DAP12-associated immunoreceptor, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Siglecs are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type lectins. Siglec-15 consisting of immunoglobulin (Ig)-like domains, transmembrane domain and a short cytoplasmic tail. Siglec-15 is that recognizes sialylated glycans and regulates osteoclast differentiation. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
DS-1501 DS-1501 Phase 1 Clinical Daiichi Sankyo Co Ltd Osteoporosis Details
NC-318 NC-318; 5G-12 Phase 2 Clinical Yale School Of Medicine Solid tumours; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Breast Neoplasms; Cholangiocarcinoma; Lung Neoplasms; Endometrial Neoplasms; Carcinoma, Non-Small-Cell Lung; Melanoma Details
PYX-106 BSI-060T; PYX-106 Phase 1 Clinical Boaoxin Biotechnology(Nanjing) Co Ltd Solid tumours Details

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