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Your Position: ホーム > IL-12B & IL-12A

IL-12B & IL-12A

概要

Name:Interleukin-12
Target Synonym:Interleukin-12
Number of Launched Drugs:4
Number of Drugs in Clinical Trials:43
Lastest Research Phase:Approved

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製造番号 種類 製品説明 構造 純度 特徴
IL2-H5210 Human Human IL-12 Protein, premium grade
IL2-H5210-sds
IL2-H8210 Human Biotinylated Human IL-12B&IL-12A Heterodimer Protein, His,Avitag™&Flag Tag
IL2-H8210-structure
IL2-H8210-sds
IL2-H4210 Human Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag
IL2-H4210-structure
IL2-H4210-sds
ACRO Quality

生物活性データの一部

IL2-H5210-Cell-based assay
IL-12B & IL-12A CELL

Human IL-12 Protein, premium grade (Cat. No. IL2-H5210) stimulates secretion of IFN-γ by NK-92 human natural killer lymphoma cells. The specific activity of Human IL-12 Protein, premium grade is > 1.00ⅹ10^7 IU/mg, which is calibrated against human IL-12 WHO International Standard (NIBSC code: 95/544) (QC tested).

Protocol
IL2-H4210-Cell-based assay
IL-12B & IL-12A CELL

Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag (Cat. No. IL2-H4210) stimulates the proliferation of PHA-P activated PBMC. The ED50 for this effect is 0.05 ng/mL (Routinely tested).

Protocol
IL2-H4210-SPR
IL-12B & IL-12A SPR

Human IL-12 R beta 1, Fc Tag (Cat. No. ILB-H5255) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag (Cat. No. IL2-H4210) with an affinity constant of 2.06 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol
IL2-H5210-BLI
IL-12B & IL-12A BLI

Loaded Biotinylated Human IL-12 R beta 1, Fc,Avitag (Cat. No. ILB-H82F7) on SA Biosensor, can bind Human IL-12 Protein, premium grade (Cat. No. IL2-H5210) with an affinity constant of 1.7 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

IL-12B & IL-12A Molecule Synonym Name

IL12,p70,Interleukin-12

IL-12B & IL-12A Molecule Background

Interleukin 12 (IL12) is also known as p70, and is an interleukin that is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation.IL12 is a heterodimeric cytokine, containing IL-12A (p35) and IL-12B (p40). IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of IFN-γ and TNF-α from T cells and NK cells, and reduces IL-4 mediated suppression of IFN-γ. IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels.

IL-12B & IL-12A References

公開薬物情報

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Thalidomide NSC-66847; NSC-527179; K-17; VP-02 Approved Celgene Corp Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled Japan Leprosy, Lepromatous Fujimoto Pharmaceutical 1982-01-01 Osteosarcoma; Leprosy, Lepromatous; Drug Resistant Epilepsy; Primary Myelofibrosis; Neuroectodermal Tumors, Primitive; Prostatitis; Colorectal Neoplasms; Lymphoma, Mantle-Cell; Sarcoma, Ewing; Retinoblastoma; Waldenstrom Macroglobulinemia; Cholangitis, Sclerosing; HIV Wasting Syndrome; Arachnoiditis; Adenocarcinoma, Clear Cell; Prostatic Neoplasms; Pancreatitis, Chronic; Lymphoma, Follicular; Sarcoma; Xerostomia; Burning Mouth Syndrome; Neoplasm Metastasis; Mycobacterium avium-intracellulare Infection; Vascular Malformations; Amyotrophic Lateral Sclerosis; Melanoma; Carcinoma, Hepatocellular; Leukemia, Lymphocytic, Chronic, B-Cell; Myelodysplastic-Myeloproliferative Diseases; Stomatitis; Erythema Nodosum; Anemia, Sideroblastic; Uterine Neoplasms; Lymphoma, Non-Hodgkin; Glioma; Angiodysplasia; Pelvic Pain; Appendiceal Neoplasms; Lung Neoplasms; Endometrial Neoplasms; Mycobacterium Infections; Gastric Antral Vascular Ectasia; Carcinoid Tumor; Lupus Erythematosus, Discoid; Stomatitis, Aphthous; Rhabdomyosarcoma; Details
Ustekinumab CNTO-1275; C-340; AVT-04 Approved Janssen Global Services Llc Stelara Mainland China Plaque psoriasis Janssen-Cilag International Nv 2009-01-15 Multiple Sclerosis; Dermatitis, Atopic; Plaque psoriasis; Crohn Disease; Uveitis; Common Variable Immunodeficiency; Hidradenitis Suppurativa; Colitis, Ulcerative; Arthritis, Psoriatic; Takayasu Arteritis; Lupus Erythematosus, Systemic; Psoriasis; Diabetes Mellitus, Type 1; Arthritis, Juvenile; Sjogren's Syndrome; Spondylitis, Ankylosing; Ichthyosis; Pouchitis; Inflammatory Bowel Diseases; Dermatomyositis; Type I Leukocyte Adhesion Defect; Polymyositis; Liver Cirrhosis, Biliary Details

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
EGFR IL12 CART Phase 1 Clinical Shenzhen Prekin Biopharmaceutical Co Ltd Colorectal Neoplasms Details
VG-201 VG-201 Phase 1 Clinical ViroGin Biotech Ltd Esophageal Neoplasms; Stomach Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Ustekinumab biosimilar (BioFactura) BFI-751 BioFactura Australia Pty Ltd Details
Mycobacterium cell wall-DNA Complex (ProMetic Life Sciences) EN-3348 Prometic Life Sciences Details
GX-51 GX-051 Pocastem, Genexine Inc Details
NSC-733972 M-032; M032-H SV-1; NSC-733972 University Of Alabama At Birmingham Details
Ustekinumab biosimilar(Formycon) FYB-202 Phase 3 Clinical Formycon Psoriasis Details
Lisofylline BL-194; CT-1501R; A-802710 Phase 3 Clinical Cti Biopharma Corp Diabetes Mellitus, Type 1; Rejection of organ transplantation Details
Ustekinumab Biosimilar (NeuClone/Serum Institute of India) Phase 1 Clinical Neuclone, Serum Institute Of India Ltd Autoimmune Diseases Details
Apilimod mesilate STA-5326-mesylate; LAM-002; LAM-002A; STA-5326; AIT-101 Phase 2 Clinical Lam, Synta Pharmaceuticals Corp Coronavirus Disease 2019 (COVID-19); Arthritis, Rheumatoid; Common Variable Immunodeficiency; Crohn Disease; Amyotrophic Lateral Sclerosis Details
Ustekinumab biosimilar(DM Bio) DA-3115; DMB-3115 Phase 3 Clinical Meiji Seika Pharma Co Ltd, Dong-A Pharmaceutical Co Ltd Psoriasis Details
ABOD-2011 ABOD-2011 Phase 1 Clinical Cancer Hospital Of Chinese Academy Of Medical Sciences Solid tumours Details
MEDI-9253 Phase 1 Clinical Astrazeneca Pharmaceutical Co Ltd Solid tumours; Neoplasms Details
MEDI-1191 MEDI-1191; MEDI1191 Phase 1 Clinical Moderna Inc Solid tumours; Neoplasms Details
DF-6002 DF-6002 Phase 2 Clinical Dragonfly Therapeutics Llc Solid tumours; Neoplasms Details
ONCR-177 ONCR-177 Phase 1 Clinical Oncorus Inc Solid tumours; Liver Neoplasms; Squamous Cell Carcinoma of Head and Neck; Skin Neoplasms; Triple Negative Breast Neoplasms; Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Melanoma Details
Ustekinumab biosimilar(CSPC Pharma) Phase 1 Clinical Jushi Biopharmaceutical Co Ltd Plaque psoriasis Details
Recombinant Human IL12/15-PDL1B Herpes Simplex Type I Oncolytic Virus(CNBG) VG-161 Phase 2 Clinical Cnbg-Virogin Biotech (Shanghai) Ltd Liver Neoplasms; Solid tumours; Biliary Tract Neoplasms; Esophageal Neoplasms; Pancreatic Neoplasms; Neoplasms; Cholangiocarcinoma; Carcinoma, Hepatocellular Details
INO-9012/Human papillomavirus vaccine INO-3112; INO-9012/VGX-3100; VGX-3100/INO-9012 Phase 2 Clinical University Of Pennsylvania, Astrazeneca Plc, Inovio Pharmaceuticals Inc Anus Neoplasms; Vaginal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Papillomavirus Infections; Neoplasms; Carcinoma, Transitional Cell; Vulvar Neoplasms; Oropharyngeal Neoplasms; Penile Neoplasms; Uterine Cervical Neoplasms Details
NHS-IL-12 M-9241; MSB-0010360 Phase 2 Clinical National Cancer Institute, Emd Serono Inc, Merck Serono Vulvar Neoplasms; Sarcoma, Kaposi; Uterine Cervical Neoplasms; Urogenital Neoplasms; Penile Neoplasms; Colorectal Neoplasms; Bile Duct Neoplasms; Oropharyngeal Neoplasms; Prostatic Neoplasms; Cholangiocarcinoma; Head and Neck Neoplasms; Urinary Bladder Neoplasms; Colonic Neoplasms; Papillomavirus Infections; Pancreatic Neoplasms; Carcinoma; Rectal Neoplasms; Vaginal Neoplasms; Anus Neoplasms; Intestinal Neoplasms Details
Rocakinogene sifuplasmid INO-9012 Phase 2 Clinical Inovio Pharmaceuticals Inc Carcinoma, Transitional Cell; Carcinoma, Hepatocellular; Precancerous Conditions; Lung Neoplasms; Vulvar Diseases; Squamous Intraepithelial Lesions of the Cervix; Colorectal Neoplasms; Hepatitis C; Breast Neoplasms; Prostatic Neoplasms; Lymphoma, Mantle-Cell; Papillomavirus Infections; Ovarian Neoplasms; Neoplasms, Glandular and Epithelial; Pancreatic Neoplasms; Urogenital Abnormalities; Glioblastoma; Esophageal Neoplasms; Stomach Neoplasms; Hepatitis, Chronic; Head and Neck Neoplasms; HIV Infections; Liver Neoplasms Details
Ustekinumab biosimilar(Amgen) ABP-654 Phase 3 Clinical Amgen Inc Solid tumours; Psoriasis Details
T3011 MVR-T3011; T3011; MVR-T3011 IT; MVR-T3011 IV Phase 2 Clinical Immvira Co Ltd Breast Neoplasms; Carcinoma, Hepatocellular; Melanoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Endometrial Neoplasms; Lymphoma; Lung Neoplasms; Colorectal Neoplasms; Solid tumours; Sarcoma; Mesothelioma; Skin Neoplasms; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Head and Neck Neoplasms; Ovarian Neoplasms; Liver Neoplasms Details
WTX-124 WTX-124 Phase 1 Clinical Werewolf Therapeutics Inc Solid tumours; Neoplasm Metastasis Details
JCXH-211 JCXH-211 Phase 1 Clinical Jiachen Xihai(Hangzhou)Biotechnology Co Ltd Solid tumours; Skin Neoplasms Details
Ustekinumab Biosimilar(Celltrion) CT-P43 Phase 3 Clinical Celltrion Inc Psoriasis Details
Veledimex INXN-1001; AD-1001 Phase 2 Clinical Ziopharm Oncology Inc Glioblastoma; Brain Neoplasms; Breast Neoplasms; Astrocytoma; Diffuse Intrinsic Pontine Glioma; Melanoma Details
Ustekinumab Biosimilar (qyuns) QX-001-S; HDM-3001; QX-001S Phase 3 Clinical Qyuns Therapeutics Co Ltd Psoriasis; Plaque psoriasis Details
MVR-C5252 C-5252; MVR-C5252 Phase 1 Clinical Immvira Co Ltd Solid tumours; Glioblastoma; Ganglioglioma; Brain Neoplasms Details
Interleukin-12 gene therapy (OncoSec Medical) pIL-12; DNA IL-12 Phase 2 Clinical Inovio Pharmaceuticals Inc Breast Neoplasms; Mycosis Fungoides; Melanoma; Carcinoma, Hepatocellular; Lymphoma, T-Cell, Cutaneous; Lung Neoplasms; Colorectal Neoplasms; Prostatic Neoplasms; Hepatitis B; Lymphoma, Mantle-Cell; HIV Infections; Triple Negative Breast Neoplasms; Pancreatic Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Merkel Cell; Esophageal Neoplasms; Stomach Neoplasms; Head and Neck Neoplasms; Ovarian Neoplasms Details
Ustekinumab biosimilar (Bio-Thera ) BAT-2206 Phase 3 Clinical Bio-Thera Solutions Ltd Autoimmune Diseases; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis Details

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