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Your Position: ホーム > BAFFR

BAFFR

概要

Name:B-cell activating factor receptor
Target Synonym:BAFFR,B Cell-Activating Factor Receptor,Prolixin,BROMIX,CD268,Tumor Necrosis Factor Receptor Superfamily, Member 13C,Tumor Necrosis Factor Receptor Superfamily Member 13C,BR3,CVID4,CD268 Antigen,BAFF Receptor,B-Cell Activation Factor Receptor,BAFF-R,TNF Receptor Superfamily Member 13C,BLyS Receptor 3,B-Cell-Activating Factor Receptor,TNFRSF13C
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Phase 3 Clinical

Antibody Licensing

Project Name Project Stage Molecule Type Host Species Therapeutic Area Indications
BAFFR&CD3 BsAb - 01 PCC Hematological Malignancy,AutoImmunity Blood tumor,Autoimmune disease

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製造番号 種類 製品説明 構造 純度 特徴
BAR-HP2H6 Human PE-Labeled Human BAFFR / TNFRSF13C Protein, His Tag (Site-specific conjugation)
BAR-HP2H6-structure
BAR-M52H8 Mouse Mouse BAFFR / TNFRSF13C Protein, His Tag
BAR-M52H8-structure
BAR-M52H8-sds
BAR-R52H3 Rat Rat BAFFR / TNFRSF13C Protein, His Tag
BAR-R52H3-structure
BAR-R52H3-sds
BAR-C52H4 Cynomolgus Cynomolgus BAFFR / TNFRSF13C Protein, His Tag (MALS verified)
BAR-C52H4-structure
BAR-C52H4-sds
BAR-H52H3 Human Human BAFFR / TNFRSF13C Protein, His Tag (MALS verified)
BAR-H52H3-structure
BAR-H52H3-sds
BAR-H82E3 Human Biotinylated Human BAFFR / TNFRSF13C Protein, His,Avitag™ (MALS verified)
BAR-H82E3-structure
BAR-H82E3-sds
BAR-H5258 Human Human BAFFR / TNFRSF13C Protein, Llama IgG2b Fc Tag, low endotoxin
BAR-H5258-structure
BAR-H5258-sds
BAR-H5257 Human Human BAFFR / TNFRSF13C Protein, Fc Tag
BAR-H5257-structure
BAR-H5257-sds
BAR-M5259 Mouse Mouse BAFFR / TNFRSF13C Protein, Fc Tag (HPLC verified)
BAR-M5259-structure
BAR-M5259-sds
BAR-M5259-hplc
BAR-M82F0 Mouse Biotinylated Mouse BAFFR / TNFRSF13C Protein, Fc,Avitag™ (MALS verified)
BAR-M82F0-structure
BAR-M82F0-sds
ACRO Quality

生物活性データの一部

BAR-HP2H6-Cell-based assay
BAFFR FACS

5e5 of anti-BAFFR CAR-293 cells were stained with 100 μL of 1:25 dilution (4 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human BAFFR Protein, His Tag (Cat. No. BAR-HP2H6) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).

Protocol
BAR-H5258-SPR
BAFFR SPR

Immobilized Human BAFF Protein, Fc Tag (Cat. No. BAF-H5261) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human BAFFR Protein, Llama IgG2b Fc Tag (Cat. No. BAR-H5258) with an affinity constant of 44.5 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol
BAR-H5257-SPR
BAFFR SPR

Immobilized Biotinylated Human BAFF, Avitag,Fc Tag (active trimer) (MALS verified) (Cat. No. BAF-H82F3) on SA Chip can bind Human BAFFR, Fc Tag (Cat. No. BAR-H5257) with an affinity constant of 26.7 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol

カスタマーレビュー

Synonym Name

BAFFR,TNFRSF13C,BROMIX,CD268,CVID4,prolixin,BAFF-R

Background

BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), is a membrane protein of the TNF receptor superfamily which recognizes BAFF. B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.

Clinical and Translational Updates

相関分子

BAFF

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
AUR-200 AUR-200 Phase 1 Clinical Thunderbolt Pharma Inc Autoimmune Diseases Details
ESG-206 ESG-206 Phase 1 Clinical Shanghai Escugen Biotechnology Co Ltd Lymphoma Details
Ianalumab VAY-736; NOV-5 Phase 3 Clinical Morphosys Ag, Novartis Pharma Ag Lymphoma, B-Cell, Marginal Zone; Hematologic Neoplasms; Sjogren's Syndrome; Idiopathic Pulmonary Fibrosis; Arthritis, Rheumatoid; Lupus Nephritis; Multiple Sclerosis; Primary mediastinal B cell lymphoma; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Lupus Erythematosus, Systemic; Hepatitis, Autoimmune; Lymphoma, Non-Hodgkin; Pemphigus; Leukemia, Lymphocytic, Chronic, B-Cell Details

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