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Your Position: ホーム > Nectin-2

Nectin-2

概要

Name:Transmembrane protein PVRIG
Target Synonym:PVRIG,PVR Related Immunoglobulin Domain Containing,CD112 Receptor,Poliovirus Receptor-Related Immunoglobulin Domain-Containing Protein,Poliovirus Receptor Related Immunoglobulin Domain Containing,Nectin-2 Receptor,C7orf15,CD112R,Transmembrane Protein PVRIG,MGC2463
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:7
Lastest Research Phase:Phase 2 Clinical

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製造番号 種類 製品説明 構造 純度 特徴
CD2-H82E7 Human Biotinylated Human Nectin-2 / CD112 Protein, His,Avitag™ (MALS verified)
CD2-H82E7-structure
CD2-H82E7-sds
CD2-H82A3 Human Biotinylated Human Nectin-2 / CD112 Protein, Mouse IgG2a Fc,Avitag™ (MALS verified)
CD2-H82A3-structure
CD2-H82A3-sds
CD2-H5257 Human Human Nectin-2 / CD112 Protein, Mouse IgG2a Fc Tag
CD2-H5257-structure
CD2-H5257-sds
CD2-H82F8 Human Biotinylated Human Nectin-2 / CD112 Protein, Fc,Avitag™ (HPLC verified)
CD2-H82F8-structure
CD2-H82F8-sds
CD2-H82F8-hplc
PV2-H5253 Human Human Nectin-2 / CD112 Protein, Fc Tag
PV2-H5253-structure
PV2-H5253-sds
PV2-H52E2 Human Human Nectin-2 / CD112 Protein, His Tag
PV2-H52E2-structure
PV2-H52E2-sds
ACRO Quality

生物活性データの一部

CD2-H5257-BLI
Nectin-2 BLI

Loaded Human Nectin-2, Mouse IgG2a Fc Tag (Cat. No. CD2-H5257) on Protein A Biosensor, can bind Human PVRIG, His Tag (Cat. No. PVG-H52H4) with an affinity constant of 1.33 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol
PV2-H5253-BLI
Nectin-2 BLI

Loaded Human Nectin-2, Fc Tag (Cat. No. PV2-H5253) on Protein A Biosensor, can bind Human PVRIG, His Tag (Cat. No. PVG-H52H4) with an affinity constant of 0.456 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Synonym Name

CD112,Nectin-2,PVRL2

Background

Poliovirus receptor-related 2 (PVRL2) is also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB),  which is a human plasma membrane glycoprotein. PVRL2 is one of the plasma membrane components of adherens junctions. PVRL2 also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in PVRL2 gene have been associated with differences in the severity of multiple sclerosis. Also, PVRL2 binds with low affinity to TIGIT. Furthermore, PVRL2 acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).

Clinical and Translational Updates

相関分子

TIGIT DNAM-1

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