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TNFR1

概要

Name:Tumor necrosis factor receptor superfamily member 1A
Target Synonym:Tumor necrosis factor receptor 1,TNF-R1,Tumor necrosis factor receptor type I,TNF-RI,TNFR-I,CD120a,TNF Receptor Superfamily Member 1A,TNFAR,Tumor Necrosis Factor Receptor Superfamily Member 1A,TNF-R-I,TNF-R55,TNFR60,TNF-R,TNFR1,Tumor Necrosis Factor Receptor Superfamily, Member 1A,Tumor Necrosis Factor Receptor 1A Isoform Beta,Tumor Necrosis Factor Binding Protein 1,Tumor Necrosis Factor Receptor Type 1,Tumor Necrosis Factor Receptor Type I,Tumor Necrosis Factor-Alpha Receptor,Tumor Necrosis Fac
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 3 Clinical

製品リスト製品比較と製品注文

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製造番号 種類 製品説明 構造 純度 特徴
TN1-H5251 Human Human TNFR1 / CD120a / TNFRSF1A Protein, Fc Tag (MALS verified)
TN1-H5251-structure
TN1-H5251-sds
TN1-H5222 Human Human TNFR1 / CD120a / TNFRSF1A Protein, His Tag
TN1-H5222-structure
TN1-H5222-sds
ACRO Quality

生物活性データの一部

TN1-H5222-ELISA
 TNFR1 ELISA

Immobilized Human TNF-alpha, premium grade (Cat. No. TNA-H4211) at 2 μg/mL (100 μL/well) can bind Human TNFR1, His Tag (Cat. No. TN1-H5222) with a linear range of 3-25 ng/mL (QC tested).

TN1-H5251-MALS-HPLC
TNFR1 MALS images

The purity of Human TNFR1, Fc Tag (Cat. No. TN1-H5251) is more than 85% and the molecular weight of this protein is around 100-122 kDa verified by SEC-MALS.

カスタマーレビュー

Synonym Name

TNFR1,CD120a,TNFRSF1A,FPF,TBP1,TNF-R,TNF-R-I,TNF-R55,TNFAR,TNFR55,TNFR60,p55,p60

Background

Tumor necrosis factor receptor 1 (TNF-R1) is also known as Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), TNFAR, CD antigen CD120a, which belongs to the tumor necrosis factor receptor superfamily. TNF-R1 contains one death domain and four TNFR-Cys repeats. TNF-R1 is the receptor of TNFSF2 / TNF-alpha and homotrimeric TNFSF1 / lymphotoxin - alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TNF-R1 contributes to the induction of non - cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Defects in TNFRSF1A are the cause of familial hibernian fever (FHF).

Clinical and Translational Updates

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