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TNF-beta

概要

Name:Tumor necrosis factor β
Target Synonym:TNF Superfamily Member 1,TNLG1E,LT,Lymphotoxin-alpha,TNFSF1,Tumor Necrosis Factor Ligand Superfamily Member 1,Tumor Necrosis Factor Beta,LT-alpha,LTA#TNFB,LTA,Lymphotoxin Alpha,TNF-Beta,TNFB,Lymphotoxin Alpha (TNF Superfamily, Member 1),Tumor Necrosis Factor Ligand 1E,Truncated Lymphotoxin Alpha,TNF Superfamily, Member 1
Number of Launched Drugs:15
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Approved

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製造番号 種類 製品説明 構造 純度 特徴
TNB-H52H3 Human Human TNF-beta / Lymphotoxin-alpha Protein, His Tag (MALS verified)
TNB-H52H3-structure
TNB-H52H3-sds
ACRO Quality

生物活性データの一部

TNB-H52H3-MALS-HPLC
TNF-beta MALS images

The purity of Human TNF-beta Protein, His Tag (Cat. No. TNB-H52H3) is more than 90% and the molecular weight of this protein is around 62-78 kDa verified by SEC-MALS.

TNB-H52H3-ELISA
TNF-beta ELISA

Immobilized Human TNFR1, Fc Tag (Cat. No. TN1-H5251) at 5 μg/mL (100 μL/well) can bind Human TNF-beta Protein, His Tag (Cat. No. TNB-H52H3) with a linear range of 1-20 ng/mL (QC tested).

Protocol

Synonym Name

LTA,DAMA-25N12,13-004,LT,TNFB,TNFSF1,LT-alpha,TNF-beta

Background

TNF-beta is also known as Lymphotoxin-alpha (LT-alpha or LTA), Tumor necrosis factor ligand superfamily member 1 (TNFSF1), which belongs to the tumor necrosis factor family. TNF-beta can form homotrimer with itself or form heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. The homotrimer of TNF-beta is secreted and the heterotrimer is membrane-associated. The homotrimeric form of NF-beta binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR.

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