ログイン 会員登録
icon_bulk_order一括注文 Acrobiosystems for English
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
phone
Your Position: ホーム > TFPI-2

TFPI-2

概要

Name:DNA-(apurinic or apyrimidinic site) lyase
Target Synonym:AP endonuclease 1,DNA-(apurinic or apyrimidinic site) lyase,APE1,APEN,REF-1,Apurinic-apyrimidinic endonuclease 1,APEX nuclease,REF1,APEX,APEX1,Apurinic/Apyrimidinic Endodeoxyribonuclease 1,APEX Nuclease (Multifunctional DNA Repair Enzyme) 1,Redox Factor-1,HAP1,APE,APX,APEX Nuclease (Multifunctional DNA Repair Enzyme),Deoxyribonuclease (Apurinic Or Apyrimidinic),Apurinic/Apyrimidinic (Abasic) Endonuclease,AP Endonuclease Class I,Protein REF-1,AP Lyase,APE-1,DNA-(apurinic or apyrimidinic site) end
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

製品リスト製品比較と製品注文

製品仕様別:
製品カテゴリー別:
種類別:
タグ別:
コンジュゲート:
製造番号 種類 製品説明 構造 純度 特徴
TF2-H5227 Human Human TFPI-2 Protein, His Tag
TF2-H5227-structure
TF2-H5227-sds
ACRO Quality

Synonym Name

TFPI2,PP5,REF1

Background

Tissue Factor Pathway Inhibitor 2 (TFPI­2) is also known as placental protein 5 (PP5) and retinal pigment epithelial cell factor 1 (REF­1), is a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). TFPI2 is highly abundant in the full-term placenta and widely expressed in umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy. TFPI­2 may play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa and has no effect on thrombin. Reduced synthesis of TFPI-2 has been related to numerous pathophysiological processes such as inflammation, angiogenesis, atherosclerosis, retinal degeneration and tumor growth / metastasis.

Clinical and Translational Updates

This web search service is supported by Google Inc.

totopphone