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Nectin-1

概要

Name:Pregnane X receptor
Target Synonym:SXR,Nuclear Receptor Subfamily 1, Group I, Member 2,Pregnane X Nuclear Receptor Variant 2,ONR1,PAR1,PAR2,PARq,BXR,PAR,PRR,SAR,Pregnane X Receptor,PXR,NR1I2,Nuclear Receptor Subfamily 1 Group I Member 2,Orphan Nuclear Receptor PXR,Steroid And Xenobiotic Receptor,Orphan Nuclear Receptor PAR1
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Approved

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製造番号 種類 製品説明 構造 純度 特徴
PV1-H5253 Human Human Nectin-1 / PVRL1 / CD111 Protein, Fc Tag
PV1-H5253-structure
PV1-H5253-sds
PV1-H5223 Human Human Nectin-1 / PVRL1 / CD111 Protein, His Tag
PV1-H5223-structure
PV1-H5223-sds
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生物活性データの一部

PV1-H5253-BLI
Nectin-1 BLI

Loaded Human Nectin-1, Fc Tag (Cat. No. PV1-H5253) on Protein A Biosensor, can bind Human Nectin-4, His Tag (Cat. No. NE4-H52H3) with an affinity constant of 0.271 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol
PV1-H5253-BLI
Nectin-1 BLI

Loaded Cynomolgus Nectin-4, His Tag (Cat. No. NE4-C52H4) on HIS1K Biosensor, can bind Human Nectin-1, Fc Tag (Cat. No. PV1-H5253) with an affinity constant of 0.23 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Synonym Name

PVRL1,Nectin-1,CD111,CLPED1,ED4,HIgR,HVEC,OFC7,PRR,PRR1,PVRR,PVRR1,SK-12

Background

Poliovirus receptor-related protein 1 (PVRL1) is also known as Herpes virus entry mediator C (HveC), Herpesvirus Ig-like receptor (HIgR), Nectin-1, CD antigen CD111, PVRL1 / Nectin-1 / CD111 belongs to the nectin family. PVRL1 / Nectin-1 is a membrane protein with three extracellular immunoglobulin domains, a single transmembrane helix and a cytoplasmic tail. The protein can mediate Ca2+-independent cellular adhesion further characterizing it as IgSF cell adhesion molecule (IgSF CAM). PVRL1 is adhesion molecule found in a wide range of tissues. PVRL1 / Nectin-1 promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4.

Clinical and Translational Updates

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