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Your Position: ホーム > LILRB2

LILRB2

概要

Name:Leukocyte immunoglobulin-like receptor subfamily B member 2
Target Synonym:Leukocyte immunoglobulin-like receptor 2,CD85 antigen-like family member D,Immunoglobulin-like transcript 4,ILT-4,Monocyte/macrophage immunoglobulin-like receptor 10,MIR-10,CD_antigen: CD85d,LILRB2,Leukocyte Immunoglobulin Like Receptor B2,Leucocyte Ig-Like Receptor B2,MIR10,Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 2,Ig-Like Transcript 4,Myeloid Inhibitory Receptor 10,CD85d Antigen,ILT4,LIR2,CD85d,LIR-2,LIRB2
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:9
Lastest Research Phase:Phase 2 Clinical

Antibody Licensing

Project Name Project Stage Molecule Type Host Species Therapeutic Area Indications
LILRB2 mAb - 01 PCC Solid Tumor Solid tumor

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製造番号 種類 製品説明 構造 純度 特徴
LI2-H5253 Human Human LILRB2 / CD85d / ILT4 Protein, Fc Tag (MALS verified)
LI2-H5253-structure
LI2-H5253-sds
LI2-H82E7 Human Biotinylated Human LILRB2 / CD85d / ILT4 Protein, His,Avitag™ (MALS verified)
LI2-H82E7-structure
LI2-H82E7-sds
LI2-C52H3 Cynomolgus Cynomolgus LILRB2 / CD85d / ILT4 Protein, His Tag
LI2-C52H3-structure
LI2-C52H3-sds
LI2-C82E3 Cynomolgus Biotinylated Cynomolgus LILRB2 / CD85d / ILT4 Protein, His,Avitag™
LI2-C82E3-structure
LI2-C82E3-sds
LI2-H82F5 Human Biotinylated Human LILRB2 / CD85d / ILT4 Protein, Fc,Avitag™ (MALS verified)
LI2-H82F5-structure
LI2-H82F5-sds
LI2-H5220 Human Human LILRB2 / CD85d / ILT4 Protein, His Tag (MALS verified)
LI2-H5220-structure
LI2-H5220-sds
ACRO Quality

生物活性データの一部

LI2-H82E7-ELISA
LILRB2 ELISA

Immobilized Anti-LILRB2 Antibody, Human IgG1 at 2 μg/mL (100 μL/well) can bind Biotinylated Human LILRB2 Protein, His,Avitag (Cat. No. LI2-H82E7) with a linear range of 0.3-20 ng/mL (QC tested).

Protocol
LI2-H5253-MALS-HPLC
LILRB2 MALS images

The purity of Human LILRB2, Fc Tag (Cat. No. LI2-H5253) is more than 95% and the molecular weight of this protein is around 160-190 kDa verified by SEC-MALS.

Synonym Name

LILRB2,ILT4,LIR2,MIR10,CD85d

Background

Leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2) is also known as CD85 antigen-like family member D (CD85d), Immunoglobulin-like transcript 4 (ILT-4), Monocyte / macrophage immunoglobulin-like receptor 10 (MIR-10), which is a member of the the subfamily B class of LIR receptors. LILRB2 is receptor for class I MHC antigens. LILRB2 recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. LILRB2 competes with CD8A for binding to class I MHC antigens. LILRB2 / CD85d inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Clinical and Translational Updates

相関分子

ANGPTL7

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
NGM-707 NGM-707 Phase 2 Clinical Merck & Co, Ngm Biopharmaceuticals Inc Ovarian Neoplasms; Stomach Neoplasms; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Glioblastoma; Mesothelioma; Cholangiocarcinoma; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung; Melanoma; Uterine Cervical Neoplasms Details
JTX-8064 JTX-8064 Phase 2 Clinical Jounce Therapeutics Inc Neoplasms Details
IO-108 IO-108 Phase 1 Clinical Solid tumours Details
MK-4830 MK-4830 Phase 2 Clinical Merck Sharp & Dohme Corp Solid tumours; Carcinoma, Renal Cell; Esophageal Neoplasms; Carcinoma, Ovarian Epithelial; Small Cell Lung Carcinoma; uterine serous carcinoma; Esophageal Squamous Cell Carcinoma; Carcinoma, Non-Small-Cell Lung Details

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