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Bcl-x

概要

Name:Apoptosis regulator Bcl-X
Target Synonym:Bcl-2-like protein 1,Bcl2-L-1,BCL2L,Apoptosis regulator Bcl-X,BCL2L1,BCL2 Like 1,Protein Phosphatase 1, Regulatory Subunit 52,BCLX,BCL-XL/S,PPP1R52,Bcl-X,bcl-X Protein,Bcl-XL,Bcl-XS
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:7
Lastest Research Phase:Approved

製品リスト製品比較と製品注文

製品仕様別:
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製造番号 種類 製品説明 構造 純度 特徴
BC1-H513a Human Human Bcl-x / BCL2L1 Protein, GST Tag
BC1-H513a-structure
BC1-H513a-sds
BC1-H5120 Human Human Bcl-x / BCL2L1 Protein, His Tag
BC1-H5120-structure
BC1-H5120-sds
ACRO Quality

Synonym Name

BCL2L1,Bcl-XL,Bcl2-L-1,BCL-XL/S,BCL2L,BCLX,BCLXL,BCLXS,Bcl-X,bcl-xS

Background

Bcl-2-like protein 1 (BCL2L1), is also known as Apoptosis regulator Bcl-X (Bcl-XL). BCL2L1 / Bcl-XL is a homodimer protein and belongs to the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a potent inhibitor of cell death. BCL2L1 Inhibits activation of caspases. BCL2L1 appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. BCL2L1 / Bcl-XL also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.

Clinical and Translational Updates

公開薬物情報

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Gossypol acetic acid/Potassium Chloride/Vitamin B1/Vitamin B6 Approved Mainland China Uterine Hemorrhage; Uterine Neoplasms; Endometriosis Xi'An Beifang Medicine Co Ltd 1988-01-01 Endometriosis; Uterine Hemorrhage; Uterine Neoplasms Details

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
UBX-1325 UBX-1325 Unity Biotechnology Inc, Ascentage Pharma Group International Details
DT-2216 DT-2216 Dialectic Therapeutics Inc, University Of Florida Details
LP-118 LP-118 Phase 1 Clinical Guangzhou Lupeng Pharmaceutical Co Ltd, Newave Pharmaceutical Inc Lymphoma, B-Cell; Solid tumours; Leukemia; Bone Marrow Neoplasms; Neoplasms; Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic; Multiple Myeloma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Leukemia, Prolymphocytic, T-Cell; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell Details
AZD-0466 AZD-0466 Phase 2 Clinical Astrazeneca Pharmaceutical Co Ltd Hematologic Neoplasms; Solid tumours; Neoplasms; Multiple Myeloma; Lymphoma, Non-Hodgkin; Lymphoma Details
R-(-)-gossypol acetic acid AT-101; BL-193; TW-37 Phase 2 Clinical University Of Michigan, Jiangsu Yasheng Pharmaceutical Development Co Ltd Lymphoma, Mantle-Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Carcinoma, Non-Small-Cell Lung; Waldenstrom Macroglobulinemia; Burkitt Lymphoma; Lymphoma, T-Cell; Lymphoma; Lymphoma, Non-Hodgkin; Laryngeal Neoplasms; Gliosarcoma; Prostatic Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Brain Neoplasms; Lymphoma, Follicular; Lymphoma, B-Cell, Marginal Zone; Central Nervous System Neoplasms; Adrenocortical Carcinoma; Multiple Myeloma; Small Cell Lung Carcinoma; Glioblastoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Immunoblastic; Lymphomatoid Granulomatosis; Leukemia, Lymphoid; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Solid tumours; Lymphoma, T-Cell, Peripheral Details
Pelcitoclax BM-1252; APG-1252 Phase 2 Clinical Jiangsu Yasheng Pharmaceutical Development Co Ltd Solid tumours; Small Cell Lung Carcinoma; Neuroendocrine Tumors; Lymphoma, Extranodal NK-T-Cell; Primary Myelofibrosis; Lymphoma, Non-Hodgkin; Carcinoma, Non-Small-Cell Lung Details

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