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IL-7

概要

Name:Interleukin-7
Target Synonym:Interleukin 7,IL7
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 1 Clinical

製品リスト製品比較と製品注文

ACRO Quality

生物活性データの一部

GMP-L07H24-Cell-based assay
 IL-7 CELL

GMP Human IL-7 Protein (Cat. No. GMP-L07H24) stimulates proliferation of PHA-P-activated human peripheral blood mononuclear cell (PBMC). The specific activity of GMP Human IL-7 is > 1.00×10^8 IU/mg, which is calibrated against human IL-7 WHO International Standard (NIBSC code: 90/530) (QC tested).

IL7-H4219-Cell-based assay
 IL-7 CELL

Human IL-7, premium grade (Cat. No. IL7-H4219) stimulates proliferation of PHA-P-activated human peripheral blood mononuclear cell (PBMC). The specific activity of Human IL-7, premium grade is > 1.00×10^8 IU/mg, which is calibrated against human IL-7 WHO International Standard (NIBSC code: 90/530) (QC tested).

IL7-Y84-SPR
 IL-7 SPR

Mouse IL-7 Antibody, Mouse IgG1 (4C9F12) (Cat. No. IL7-Y84) immobilized on CM5 Chip can bind Human IL-7, premium grade (Cat. No. IL7-H4219) with an affinity constant of 2.83 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

IL7-M52H3-ELISA
 IL-7 ELISA

Immobilized Mouse IL-7 Protein, His Tag (Cat. No. IL7-M52H3) at 2 μg/mL (100 μL/well) can bind Human IL-7 R alpha, Mouse IgG2a Fc Tag (Cat. No. IL7-H5258) with a linear range of 0.2-2 ng/mL (QC tested).

Synonym Name

IL7,Interleukin-7

Background

Interleukin 7 is also known as IL7, IL-7, and is a hematopoietic growth factor secreted by stromal cells in the red marrow and thymus. It is also produced by keratinocytes, dendritic cells, hepatocytes, neurons, and epithelial cells, but is not produced by lymphocytes. IL-7 stimulates the differentiation of multipotent (pluripotent) hematopoietic stem cells into lymphoid progenitor cells, It also stimulates proliferation of all cells in the lymphoid lineage (B cells, T cells and NK cells). It is important for proliferation during certain stages of B-cell maturation, T and NK cell survival, development and homeostasis. IL-7 is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. IL-7 binds to the IL-7 receptor, a heterodimer consisting of Interleukin-7 receptor alpha and common gamma chain receptor. Il-7 promotes hematological malignacies (acute lymphoblastic leukemia, T cell lymphoma). Elevated levels of IL-7 have also been detected in the plasma of HIV-infected patients. IL-7 as an immunotherapy agent has been examined in many pre-clinical animal studies and more recently in human clinical trials for various malignancies and during HIV infection. IL-7 could also be beneficial in improving immune recovery after allogenic stem cell transplant.

Clinical and Translational Updates

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