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gp130

概要

Name:Interleukin-6 receptor subunit beta
Target Synonym:IL6ST,Oncostatin-M Receptor Subunit Alpha,CD130,Interleukin-6 Signal Transducer,Interleukin-6 Receptor Subunit Beta,Gp130 Of The Rheumatoid Arthritis Antigenic Peptide-Bearing Soluble Form,CD130 Antigen,Membrane Glycoprotein Gp130,SGP130,IL-6R-Beta,HIES4,Gp130, Oncostatin M Receptor,IL-6RB,GP130,Cytokine Receptor gp130,Interleukin 6 Signal Transducer,Membrane Glycoprotein 130,Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor),CDW130,IL-6 Receptor Subunit Beta,Interleukin Receptor Bet
Number of Launched Drugs:6
Number of Drugs in Clinical Trials:12
Lastest Research Phase:Approved

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製造番号 種類 製品説明 構造 純度 特徴
ILT-M5252 Mouse Mouse gp130 / CD130 / IL-6 R beta Protein, Fc Tag
ILT-M5252-structure
ILT-M5252-sds
ILT-M52H1 Mouse Mouse gp130 / CD130 / IL-6 R beta Protein, His Tag
ILT-M52H1-structure
ILT-M52H1-sds
ACRO Quality

Synonym Name

IL6ST,gp130,CD130,IL-6RB,IL-6R-beta,CDw130

Background

Interleukin-6 receptor subunit beta (IL6ST) is also known as IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, Interleukin-6 signal transducer, Membrane glycoprotein 130 (gp130), CD130, Oncostatin-M receptor subunit alpha and Il6st,which is single-pass type I membrane protein. IL6ST /gp130 /CD130 can be found in tissues such as brain, heart, thymus, spleen, kidney, lung and liver and found in all the cell lines tested except BaF-B03.The expression of IL-6ST /gp130 is not restricted to IL6-responsive cells. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. IL6ST /CD130 can bind to IL6 /IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduce the signal. IL6ST /GP130 does not bind IL6 and may have a role in embryonic development.

Clinical and Translational Updates

公開薬物情報

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Sarilumab REGN-88; SAR-153191 Approved Sanofi, Regeneron Pharmaceuticals Inc Kevzara Japan Arthritis, Rheumatoid Sanofi 2017-05-22 Arthritis, Rheumatoid; Spondylitis, Ankylosing; Coronavirus Disease 2019 (COVID-19); Sarcoidosis; Mastocytosis, Systemic; Arthritis, Juvenile; Coronavirus Infections; Severe Acute Respiratory Syndrome; Uveitis Details
Satralizumab RG-6168; SA-237 Approved Chugai Pharmaceutical Co Ltd Enspryng, エンスプリング EU Neuromyelitis Optica Roche Registration Gmbh 2020-06-29 Myasthenia Gravis; Neuromyelitis Optica; Anti-N-Methyl-D-Aspartate Receptor Encephalitis Details
Tocilizumab R-1569; rhPM-1; RG-1569; RO-48775533; MRA; HPM-1; MRA-SC Approved Chugai Pharmaceutical Co Ltd Actemra, RoActemra, Actemra/RoActemra, 雅美罗 EU Coronavirus Disease 2019 (COVID-19) Roche Registration Gmbh 2005-04-11 Pulmonary Disease, Chronic Obstructive; Stroke; Graves Ophthalmopathy; Coronavirus Infections; Coronary Disease; Takayasu Arteritis; Multicentric Castleman's Disease (MCD); Severe Acute Respiratory Syndrome; Lupus Erythematosus, Systemic; systemic sclerosis-associated interstitial lung disease; Pulmonary Arterial Hypertension; Breast Neoplasms; Fever; Respiratory Distress Syndrome, Adult; Uveitis, Posterior; Inflammation; Uveitis; Lymphoma; Osteoarthritis; Rejection in heart transplantation; Carcinoma, Hepatocellular; Non-ST Elevated Myocardial Infarction; Amyotrophic Lateral Sclerosis; Behcet Syndrome; Diabetes Mellitus; Kidney Failure, Chronic; Depressive Disorder, Major; Diabetes Mellitus, Type 1; Hematologic Neoplasms; Solid tumours; Motor Neuron Disease; Craniopharyngioma; Polymyositis; HIV Infections; Uveitis, Intermediate; Myocardial Infarction; Giant Cell Arteritis; Schnitzler Syndrome; Pneumonia; Cytokine Release Syndrome; Dermatomyositis; Polyarticular Juvenile Idiopathic Arthritis; Arthritis, Rheum Details

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
Tocilizumab biosimilar (AryoGen Pharmed) Phase 3 Clinical Aryogen Biopharma Arthritis, Rheumatoid Details
CMAB806 CMAB-806 Phase 3 Clinical Taizhou Maibo Taike Biotechnology Co Ltd Arthritis, Rheumatoid; Arthritis Details
Recombinant humanized anti-IL-6R antibody (Hisun Pharma) HS-628 Phase 3 Clinical Zhejiang Hisun Pharmaceutical Co Ltd Arthritis, Rheumatoid; Arthritis Details
Levilimab BCD-089 Phase 3 Clinical Biocad Coronavirus Disease 2019 (COVID-19); Arthritis, Rheumatoid Details
VDJ-001 Phase 2 Clinical Beijing Vdjbio Co Ltd Arthritis, Rheumatoid; Multicentric Castleman's Disease (MCD) Details
Olamkicept TJ-301; FE-999301; CR-5/18; FE-301 Phase 2 Clinical Conaris Research Institute Colitis, Ulcerative Details
Tocilizumab biosimilar (Fresenius kabi) MSB-11456 Phase 3 Clinical Merck Serono Arthritis, Rheumatoid Details
Atexakin alfa SON-080; r-IL-6 Phase 2 Clinical Merck Serono, Weizmann Institute Of Science Peripheral Nervous System Diseases; Diabetic Neuropathies Details
Tocilizumab biosimilar (Celltrion) CT-P47; CT-P-47 Phase 3 Clinical Celltrion Inc Arthritis, Rheumatoid Details

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