ログイン 会員登録
icon_bulk_order一括注文 Acrobiosystems for English
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
phone
Your Position: ホーム > IL-5 R alpha

IL-5 R alpha

概要

Name:Interleukin-5 receptor subunit alpha
Target Synonym:Interleukin 5 Receptor, Alpha,Interleukin-5 Receptor Subunit Alpha,HSIL5R3,Interleukin-5 Receptor Alpha Chain,CDw125,Interleukin-5 Receptor alpha Subunit,Interleukin 5 Receptor Type 3,CD125 Antigen,Interleukin 5 Receptor Subunit Alpha,IL-5 Receptor Subunit Alpha,IL-5R-Alpha,IL5R,IL5RA,CD125,IL-5RA,IL-5R Subunit Alpha
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Approved

製品リスト製品比較と製品注文

ACRO Quality

生物活性データの一部

ILA-H52H4-BLI
 IL-5 R alpha BLI

Loaded Biotinylated Human IL-5, His,Avitag (Cat. No. IL5-H82Q5) on SA Biosensor, can bind Human IL-5 R alpha, His Tag (Cat. No. ILA-H52H4) with an affinity constant of 12.6 nM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).

ILA-H5269-ELISA
 IL-5 R alpha ELISA

Immobilized Human IL-5, His Tag (Cat. No. IL5-H52H3) at 5 μg/mL (100 μL/well) can bind Human IL-5 R alpha, Fc Tag (Cat. No. ILA-H5269) with a linear range of 0.6-10 ng/mL (QC tested).

Synonym Name

IL5Ra,CD125

Background

Interleukin-5 receptor subunit alpha (IL5RA) is also known as IL-5 receptor subunit alpha, IL-5R subunit alpha and CD125,which is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and type 5 subfamily.IL5R, a heterodimer of an alpha and a beta subunit, is expressed on eosinophils and basophils. IL5RA / CD125 is the receptor for interleukin-5 (IL5) and the alpha chain can bind to IL5. The WSXWS motif of IL5RA appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.The beta subunit of IL5R is common to the IL3, IL5 and GM-CSF receptors.

Clinical and Translational Updates

公開薬物情報

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Benralizumab BIW-8405; KHK-4563; MEDI-563; BIW-8405-IL-5R Approved Biowa Inc, Medimmune Llc Fasenra Japan Asthma Astrazeneca Pharmaceutical Co Ltd 2017-11-14 Bronchiectasis; Gastroenteritis; Hypersensitivity; Eczema; Dermatitis, Atopic; Skin Diseases, Genetic; Hypersensitivity, Immediate; Pulmonary Disease, Chronic Obstructive; Sinusitis; Leukocyte Disorders; Asthma; Pemphigoid, Bullous; Eosinophilic Esophagitis; Eosinophilic gastroenteritis (EG); Immune System Diseases; Skin Diseases, Eczematous; Dermatitis; Skin Diseases; Genetic Diseases, Inborn; Nasal Polyps; Eosinophilia; Respiratory Tract Diseases; Chronic Urticaria; Asthma, Exercise-Induced; Hematologic Diseases; Hypereosinophilic Syndrome Details

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
CSL-311 CSL-311 Csl Ltd Details

This web search service is supported by Google Inc.

totopphone