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Your Position: ホーム > IL-17 RA

IL-17 RA

概要

Name:Interleukin-17 receptor A
Target Synonym:CDw217,IL-17 receptor A,IL17R,IL17RA,Interleukin 17 Receptor A,IL-17RA,Interleukin 17 Receptor,CD217 Antigen,HIL-17R,CANDF5,CD217,IMD51,Interleukin-17 receptor A
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Approved

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製造番号 種類 製品説明 構造 純度 特徴
ILA-H525f Human Human IL-17 RA / CD217 Protein, Fc Tag (MALS verified)
ILA-H525f-sds
ILR-H82E5 Human Biotinylated Human IL-17 RA / CD217 Protein, His,Avitag™
ILR-H82E5-structure
ILR-H82E5-sds
ILA-H82F1 Human Biotinylated Human IL-17 RA / CD217 Protein, Fc,Avitag™
ILA-H82F1-structure
ILA-H82F1-sds
ILA-H5222 Human Human IL-17 RA / CD217 Protein, His Tag
ILA-H5222-structure
ILA-H5222-sds
ACRO Quality

生物活性データの一部

ILA-H82F1-BLI
IL-17 RA BLI

Loaded Biotinylated Human IL-17 RA, Fc,Avitag (Cat. No. ILA-H82F1) on SA Biosensor, can bind Human IL17A, Tag Free with an affinity constant of 1.29 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol
ILA-H5222-BLI
IL-17 RA BLI

Loaded Biotinylated Human IL17A, His,Avitag (Cat. No. ILA-H82Q1) on SA Biosensor, can bind Human IL-17 RA, His Tag (Cat. No. ILA-H5222) with an affinity constant of 18.8 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Synonym Name

CD217,CDw217,IL-17RA,IL17R,CANDF5,hIL-17R

Background

Interleukin 17 receptor A (IL17RA) is also known as cluster of differentiation w217 (CDw217), is a pro-inflammatory cytokine secreted by activated T-lymphocytes, belong to ubiquitous type I membrane glycoprotein, and binds with low affinity to interleukin 17A (IL17A). IL 17R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested . IL 17RA associates with IL 17RC to form a signaling receptor complex for IL 17 and IL 17F . Ligand and IL 17RA ligation promotes T cell activation and the production of IL - 6, G-CSF, SCF, and multiple pro-inflammatory chemokines. Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5).

Clinical and Translational Updates

相関分子

TNF-alpha

公開薬物情報

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Brodalumab IL-17R mAb; MEDI-6365; KHK-4827; AMG-827 Approved Amgen Inc Siliq, Lumicef, Kyntheum, 立美芙 Mainland China Plaque psoriasis Kyowa Kirin 2016-07-04 Arthritis, Rheumatoid; Spondylitis, Ankylosing; Scleroderma, Systemic; Psoriasis; Asthma; Arthritis, Psoriatic; Hidradenitis Suppurativa; Crohn Disease; Plaque psoriasis Details

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
LY-3114062 LY3114062; LY-3114062 Eli Lilly And Company Details
XCUR-17 XCUR-17 Phase 1 Clinical Exicure Inc Psoriasis Details

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