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Your Position: ホーム > GITR

GITR

概要

Name:Glucocorticoid-induced tumor necrosis factor receptor-related protein
Target Synonym:TNFRSF18,TNF Receptor Superfamily Activation-Inducible Protein,ENERGEN,GITR-D,Tumor Necrosis Factor Receptor Superfamily Member 18,CD357 Antigen,Activation-Inducible TNFR Family Receptor,AITR,CD357,GITR,Glucocorticoid-Induced TNFR-Related Protein,Tumor Necrosis Factor Receptor Superfamily, Member 18,TNF Receptor Superfamily Member 18
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Phase 2 Clinical

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製造番号 種類 製品説明 構造 純度 特徴
GIR-M52H3 Mouse Mouse GITR / TNFRSF18 Protein, His Tag
GIR-M52H3-structure
GIR-M52H3-sds
GIR-H82E1 Human Biotinylated Human GITR / TNFRSF18 Protein, His,Avitag™ (MALS verified)
GIR-H82E1-structure
GIR-H82E1-sds
GIR-C52H6 Canine Canine GITR / TNFRSF18 Protein, His Tag
GIR-C52H6-structure
GIR-C52H6-sds
GIR-H82F7 Human Biotinylated Human GITR / TNFRSF18 Protein, Fc,Avitag™
GIR-H82F7-structure
GIR-H82F7-sds
GIR-H525a Human Human GITR / TNFRSF18 Protein, Mouse IgG2a Fc Tag, low endotoxin
GIR-H525a-structure
GIR-H525a-sds
GIR-H5254 Human Human GITR / TNFRSF18 Protein, Fc Tag
GIR-H5254-structure
GIR-H5254-sds
GIR-C5255 Rhesus macaque Rhesus macaque GITR / TNFRSF18 Protein, Fc Tag
GIR-C5255-structure
GIR-C5255-sds
GIR-R5222 Rat Rat GITR / TNFRSF18 Protein, His Tag
GIR-R5222-structure
GIR-R5222-sds
GIR-H5228 Human Human GITR / TNFRSF18 Protein, His Tag (MALS verified)
GIR-H5228-structure
GIR-H5228-sds
ACRO Quality

生物活性データの一部

GIR-H82E1-ELISA
GITR ELISA

Immobilized Human GITR Ligand, Fc Tag at 10 μg/mL (100 μL/well) can bind Biotinylated Human GITR, His,Avi tag™ (Cat. No. GIR-H82E1) with a linear range of 0.039-0.625 μg/mL (QC tested).

Protocol
GIR-H82E1-MALS-HPLC
GITR MALS images

The purity of Biotinylated Human GITR Protein, His,Avitag (Cat. No. GIR-H82E1) is more than 95% and the molecular weight of this protein is around 20-30 kDa verified by SEC-MALS.

カスタマーレビュー

Synonym Name

AITR,GITR,TNFRSF18,CD357

Background

Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.

Clinical and Translational Updates

相関分子

GITR Ligand

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
Anti-GITR antibody (BMS) Phase 1 Clinical Neoplasms Details
GWN-323 GWN-323 Novartis Pharma Ag Details
MK-1248 MK-1248 Merck Sharp & Dohme Corp Details
REGN-6569 REGN6569; REGN-6569 Phase 1 Clinical Regeneron Pharmaceuticals Inc Squamous Cell Carcinoma of Head and Neck Details
Ragifilimab INCAGN-1876; INCAGN-01876; AGEN-1876; CM-701 Phase 2 Clinical Agenus Inc, Ludwig Institute For Cancer Research Neoplasms; Neoplasm Metastasis Details
BMS-986156 BMS-986156 Phase 2 Clinical Bristol-Myers Squibb Company Solid tumours; Neoplasms Details

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