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Your Position: ホーム > FKBP12

FKBP12

概要

Name:FK506-binding protein 1A
Target Synonym:Peptidyl-Prolyl Cis-Trans Isomerase FKBP1A,FK506-Binding Protein, T-Cell, 12-KD,FK506-Binding Protein 1A (12kD),Protein Kinase C Inhibitor 2,FK506-Binding Protein 12,FK506 Binding Protein12,FK506-Binding Protein 1,FKBP12-Exip3,Calstabin 1,PPIASE,PKC12,PKCI2,Tacrolimus Binding Protein 1A,FKBP12C,FK506 Binding Protein 1A, 12kDa,12 KDa FK506-Binding Protein,Immunophilin FKBP12,12 KDa FKBP,Rotamase,FKBP Prolyl Isomerase 1A,FKBP1,FKBP12,FKBP-12,PPIase FKBP1A,FK506-binding protein 1A,Calstabin-1,FKBP-
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Approved

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FKA-H5122 Human Human FKBP12 / FKBP1A Protein, His Tag
FKA-H5122-structure
FKA-H5122-sds
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Synonym Name

FKBP1A,FKBP1,Calstabin-1,FKBP12,Rotamase,PKC12,PPIASE

Background

Peptidyl-prolyl cis-trans isomerase FKBP1A, a member of the FKBP-type PPIase family and FKBP1 subfamily, is also known as FK506-binding protein 1A, immunophilin FKBP12 and 12 kDa FK506-binding protein, which contains one PPIase FKBP-type domain. FKBP1A is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus).FKBP1A interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. FKBP1A can also interact with multiple intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor. Furthermore, FKBP1A can recruite SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal.

Clinical and Translational Updates

公開薬物情報

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Tacrolimus Hydrate FR-900506; L-679934; FK-506MR; FK-506E; FK-506; MR-4; RTU-007; LCP-Tacro Approved Astellas Pharma Inc Protopy, Graceptor (as hydrate), Protopic, Prograf (as hydrate), Hecoria (as hydrate), Hexal, Envarsus XR, Talymus, 普乐可复, Advagraf, Envarsus, Modigraf, Astagraf XL, TacroBell United States Rejection of lung transplantation Astellas Pharma Us Inc 1993-01-01 Wounds and Injuries; Rejection of organ transplantation; Lupus Nephritis; Brain Death; Psoriasis; Amputation, Traumatic; Conjunctivitis, Allergic; Colitis, Ulcerative; Asthma; Surgical Wound Infection; Keratoconjunctivitis; Rejection in heart transplantation; Lung Diseases, Interstitial; Infertility, Female; Nephrotic Syndrome; Renal Insufficiency, Chronic; Coronary Restenosis; Dermatitis, Atopic; Ocular inflammation; Encephalitis; Edema; Peripheral Nerve Injuries; Vitiligo; Crohn Disease; Dermatomyositis; Keratoconjunctivitis Sicca; Rejection of renal transplantation; Polymyositis; Bone marrow transplant rejection; Liver Failure; Genital Diseases, Male; Reperfusion Injury; Medication Adherence; Rejection of lung transplantation; Rejection of liver transplantation; Glomerulonephritis, IGA; Myasthenia Gravis; Primary Graft Dysfunction; Renal Insufficiency; Keratoplasty rejection; Cystitis; Kidney Diseases; Lupus Erythematosus, Cutaneous; Arthritis, Rheumatoid; Graft vs Host Disease; Conjunctivitis; Dry Eye Sy Details

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
Rimiducid AP-1903 Phase 1 Clinical Ariad Pharmaceuticals Inc Hematologic Neoplasms; Multiple Myeloma; Sarcoma; Neuroblastoma; Osteosarcoma; Melanoma Details

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