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DNAM-1

概要

Name:CD226 antigen
Target Synonym:DNAX accessory molecule 1,DNAM-1,T Lineage-Specific Activation Antigen 1 Antigen,PTA1,DNAX Accessory Molecule-1,Adhesion Glycoprotein,TLiSA1,DNAM1,CD226 Molecule,Platelet And T Cell Activation Antigen 1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

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製造番号 種類 製品説明 構造 純度 特徴
DN1-M52H5 Mouse Mouse DNAM-1 / CD226 Protein, His Tag (SPR verified)
DN1-M52H5-structure
DN1-M52H5-sds
DN1-C52H4 Canine Canine DNAM-1 / CD226 Protein, His Tag (SPR verified)
DN1-C52H4-structure
DN1-C52H4-sds
DN1-C52H9 Cynomolgus Cynomolgus DNAM-1 / CD226 Protein, His Tag
DN1-C52H9-structure
DN1-C52H9-sds
DN1-H82F9 Human Biotinylated Human DNAM-1 / CD226 Protein, Fc,Avitag™
DN1-H82F9-structure
DN1-H82F9-sds
DN1-H5257 Human Human DNAM-1 / CD226 Protein, Fc Tag (MALS verified)
DN1-H5257-structure
DN1-H5257-sds
DN1-H52H6 Human Human DNAM-1 / CD226 Protein, His Tag
DN1-H52H6-structure
DN1-H52H6-sds
ACRO Quality

生物活性データの一部

DN1-H82F9-Cell-based assay
DNAM-1 FACS

FACS assay shows Biotinylated Human DNAM-1, Fc,Avitag (Cat. No. DN1-H82F9) can bind to 293T cell overexpressing human CD155. The concentration of DNAM-1 is 0.03 μg/mL (Routinely tested).

Protocol
DN1-H5257-Cell-based assay
DNAM-1 FACS

FACS assay shows that recombinant Human DNAM-1 Protein, Fc Tag (Cat. No. DN1-H5257) can bind to 293T cell overexpressing human CD155. The concentration of DNAM-1 used is 0.03 μg/ml (Routinely tested).

Protocol
DN1-M52H5-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human CD155, Fc Tag (Cat. No. CD5-H5251) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Mouse DNAM-1, His Tag (Cat. No. DN1-M52H5) with an affinity constant of 0.816 μM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol
DN1-C52H4-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human CD155, Fc Tag (Cat. No. CD5-H5251) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Canine DNAM-1, His Tag (Cat. No. DN1-C52H4) with an affinity constant of 31.9 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol

Synonym Name

DNAM1,CD226,PTA1

Background

DNAX accessory molecule 1 (DNAM-1), a single-pass type I membrane protein, is also known as CD226 antigen and platelet and T cell activation antigen 1 (PTA1), which contains 2 Ig-like C2-type (immunoglobulin-like) domains. DNAM-1 is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. DNAM-1 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155, and cross-linking DNAM-1 with antibodies causes cellular activation. Furthermore, DNAM-1 can interact with PVR and PVRL2.

Clinical and Translational Updates

相関分子

CD155 Nectin-2

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