ログイン 会員登録
icon_bulk_order一括注文 Acrobiosystems for English
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
phone
Your Position: ホーム > Dkk-3

Dkk-3

概要

Name:Dickkopf-related protein 3
Target Synonym:Dickkopf 3 Homolog (Xenopus Laevis),UNQ258/PRO295,Dickkopf-3,Dickkopf-related protein 3,hDkk-3,REIC,DKK3,Dickkopf WNT Signaling Pathway Inhibitor 3,Regulated In Glioma,Dkk-3,Dickkopf (Xenopus Laevis) Homolog 3,Dickkopf 3 Homolog,Dickkopf Homolog 3,RIG-Like 5-6,RIG-Like 7-1,RIG
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

製品リスト製品比較と製品注文

製品仕様別:
製品カテゴリー別:
種類別:
タグ別:
コンジュゲート:
製造番号 種類 製品説明 構造 純度 特徴
DK3-M5226 Mouse Mouse Dkk-3 Protein, His Tag
DK3-M5226-structure
DK3-M5226-sds
DK3-H5220 Human Human Dkk-3 (R335G) Protein, His Tag
DK3-H5220-structure
DK3-H5220-sds
ACRO Quality

Synonym Name

DKK3,REIC,RIG

Background

Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
Ad-SGE-DKK3 gene therapy Ad-SGE-DKK3; Ad-SGE-REIC Phase 2 Clinical Kyorin Pharmaceutical Co Ltd Mesothelioma Details
REIC gene therapy (Momotaro-Gene) MTG-201; Ad5-SGE-REIC/Dkk-3 Phase 2 Clinical Momotaro-Gene Inc Mesothelioma; Prostatic Neoplasms Details

This web search service is supported by Google Inc.

totopphone