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SMAC

概要

Name:Diablo homolog, mitochondrial
Target Synonym:Direct IAP-binding protein with low pI,Second mitochondria-derived activator of caspase,Smac,Diablo IAP-Binding Mitochondrial Protein
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

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製造番号 種類 製品説明 構造 純度 特徴
DIO-H5129 Human Human SMAC / Diablo Protein, His Tag
DIO-H5129-structure
DIO-H5129-sds
ACRO Quality

Synonym Name

DIABLO,SMAC

Background

Diablo homolog, mitochondrial (DIABLO) is also known as direct IAP-binding protein with low pI and second mitochondria-derived activator of caspase (SMAC), which can interact with BIRC2/c-IAP1, BIRC3/c-IAP2, XIAP/BIRC4, BIRC6/bruce and BIRC7/livin. Acting by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP),DIABLO can also promote apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Also, DIABLO inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Furthermore, DIABLO is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.

Clinical and Translational Updates

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