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Your Position: ホーム > APP

APP

概要

Name:Beta amyloid A4 protein
Target Synonym:Beta-CTF,Amyloid Beta Precursor Protein,Cerebral Vascular Amyloid Peptide,Beta-Amyloid Precursor Protein,Amyloid-Beta A4 Protein,Beta-Amyloid Peptide,Alzheimer Disease,CTFgamma,ABETA,AAA,PN2,Amyloid beta-Peptides,Amyloid intracellular domain 57,APP,Amyloid intracellular domain 59,PN-II,Alpha-secretase C-terminal fragment,AICD-50,S-APP-alpha,A4,S-APP-beta,Alzheimer disease amyloid protein,Abeta40,Gamma-CTF(59),Abeta42,Gamma-CTF(57),Alpha-CTF,Amyloid intracellular domain 50,AID(59),Gamma-CTF(50),A
Number of Launched Drugs:11
Number of Drugs in Clinical Trials:39
Lastest Research Phase:Approved

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製造番号 種類 製品説明 構造 純度 特徴
APP-H52H3 Human Human APP Protein, His Tag (active enzyme, MALS verified)
APP-H52H3-structure
APP-H52H3-sds
CHEK-ATP081 Human HEK293/Human APP (GFP) Stable Cell Line
APP-H51H7 Human Human APP / Abeta40 Protein, His Tag
APP-H51H7-structure
APP-H51H7-sds
APP-H52H5 Human Human APP / SAPPbeta Protein, His Tag (MALS verified)
APP-H52H5-structure
APP-H52H5-sds
APP-M52H3 Mouse Mouse APP / N-APP Protein, His Tag (MALS verified)
APP-M52H3-structure
APP-M52H3-sds
ACRO Quality

生物活性データの一部

CHEK-ATP081-Cell-based assay
APP FACS

FACS analysis of APP (GFP) on HEK293/Human APP (GFP) Stable Cell Line.
HEK293/Human APP (GFP) Stable Cell Line was red line, negative control HEK293 cells was grey line (QC tested).

Protocol
APP-H52H3-MALS-HPLC
APP MALS images

The purity of Human APP Protein, His Tag (Cat. No. APP-H52H3) is more than 85% and the molecular weight of this protein is around 80-110 kDa verified by SEC-MALS.

APP-H52H5-MALS-HPLC
Human SAPPbeta, His Tag (Cat. No. ) MALS images

The purity of Human SAPPbeta, His Tag (Cat. No. APP-H52H5) is more than 90% and the molecular weight of this protein is around 95-115 kDa verified by SEC-MALS.

Report

Synonym Name

ABPP,APPI,Amyloid-beta A4 protein

Background

Amyloid precursor protein (APP) is  a type I integral membrane protein ubiquitously expressed in many tissues and concentrated in the synapses of neurons. It has three predominant splice variants: APP695, APP751, and APP770. The majority of APP is cleaved at the plasma membrane by the α-secretase in the non-amyloidogenic pathway.  The amyloidogenic pathway starts with β-secretase cleavage by BACE1 on the N-terminal part of the Aβ domain, releasing sAPPβ from a membrane-anchored fragment named βCTF or C99, which is subsequently cleaved by γ-secretase to release Aβ.

Clinical and Translational Updates

公開薬物情報

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Florapronol (18F) 18F-FC-119S; 18F-FC-119(S) Approved Korea Institute Of Radiological And Medical Sciences, Futurechem Alzavue Alzheimer Disease Details
L-Lysine hydrochloride/Cyanocobalamin/Inositol Approved 兴邦 Malnutrition Details
Immune Globulin Subcutaneous (Human) (Octapharma) Approved Octapharma Cutaquig, Octanorm, Gammanorm United States Immunologic Deficiency Syndromes null 2018-08-02 Immunologic Deficiency Syndromes Details
Sodium Oligomannurarate GV-971; 971 Approved Ocean University Of China, Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences 九期一 Mainland China Alzheimer Disease Shanghai Greenvalley Pharmaceutical Co Ltd 2019-11-02 Alzheimer Disease; Parkinson Disease Details
Inositol 4L6452S749 Approved Nicosit Anovulation; Depression; Anxiety; Diabetic Neuropathies; Polycystic Ovary Syndrome; Glucose Intolerance; Insulin Resistance; Infant, Newborn, Diseases; Bronchopulmonary Dysplasia; Metabolic Diseases; Lung Neoplasms; Precancerous Conditions; Retinopathy of Prematurity; Infant, Premature, Diseases; Carcinoma, Non-Small-Cell Lung; Hyperandrogenism Details
Immune globulin 10% (Grifols) KIg-10; TAL-05-0002 Approved Bayer AG Gamunex, Gammaked United States Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Purpura, Thrombocytopenic, Idiopathic; Immunologic Deficiency Syndromes null 2003-08-27 Postural Orthostatic Tachycardia Syndrome; Anemia, Sickle Cell; Corneal Neovascularization; Kidney Failure, Chronic; Immunologic Deficiency Syndromes; Muscular Diseases; Common Variable Immunodeficiency; Neuralgia; Reflex Sympathetic Dystrophy; Obsessive-Compulsive Disorder; Severe Combined Immunodeficiency; Primary Immunodeficiency Diseases; Anxiety Disorders; Autoimmune Diseases; Coronavirus Disease 2019 (COVID-19); Pain; Agammaglobulinemia; Tibial Fractures; Purpura, Thrombocytopenic, Idiopathic; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Wiskott-Aldrich Syndrome; Myasthenia Gravis Details
Flutemetamol (18F) AH-110690; GE-067; 18F-GE067 Approved Ge Healthcare Vizamyl Japan Contrast agents Nihon Medi-Physics Co Ltd 2013-10-25 Atherosclerosis; Cardiomyopathies; Breast Neoplasms; Contrast agents; Cognitive Dysfunction; Alzheimer Disease; Dementia; Diagnostic agents; Hydrocephalus, Normal Pressure; Cognition Disorders Details
Florbetapir(18F) MNI-798; AV-45 Approved Eli Lilly And Company Amyvid Japan Diagnostic agents Eli Lilly And Company 2012-04-06 Amyloidosis; Hypersensitivity; Frontotemporal Dementia; Neurodegenerative Diseases; Collagen Diseases; Eye Diseases; Diagnostic agents; Lewy Body Disease; Rheumatic Diseases; Respiration Disorders; Parkinson Disease; Cognitive Dysfunction; Alzheimer Disease; Contrast agents; Spasms, Infantile; Multiple Sclerosis; Skin Diseases Details
Aducanumab BIIB-037; NI-10; BART Approved Eisai Co Ltd, Neurimmune Ag ADUHELM United States Alzheimer Disease Biogen Inc 2021-06-07 Alzheimer Disease; Cognitive Dysfunction Details
Florbetaben (18F) MNI-815; AV-1; ZK-6013443; BAY-949172 Approved Piramal Neuraceq United States Hyponatremia Molecular Life Inc 2014-02-20 Supranuclear Palsy, Progressive; Down Syndrome; Hyponatremia; Immunoglobulin Light-chain Amyloidosis; Dementia; Alzheimer Disease; Amyloidosis Details

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
[18F]THK-5105 [18F]THK-5105 Phase 2 Clinical Tohoku University Alzheimer Disease Details
RIV-1061-IR RIV-1061; RIV-1061-IR Phase 1 Clinical Revivo Therapeutics Alzheimer Disease; Cognition Disorders Details
11C-BF-227 11C-BF-227; [11C]BF-227 Phase 2 Clinical Tohoku University Diagnostic agents Details
Abeta42 antibody (Lilly) Phase 1 Clinical Eli Lilly And Company Alzheimer Disease Details
[18F]THK-5117 [18F]THK-5117 Phase 2 Clinical Tohoku University Alzheimer Disease Details
RQ-9 AAT-009; RQ-9; RQ-00000009 Phase 1 Clinical Pfizer Inc Dementia Details
A ß antibody Fab Phase 1 Clinical Eli Lilly And Company Alzheimer Disease Details
PRX-012 PRX-012 Phase 1 Clinical Prothena Alzheimer Disease Details
ASN-120290 ASN-120290; ASN-561; ASN-90 Phase 1 Clinical Merck Serono Alzheimer Disease Details
APH-1105 APH-1105 Aphios Details
Trontinemab RO-7126209; RG-6102 F. Hoffmann-La Roche Ltd Details
E-2212 GSM-2; GSM-A; E-2212 Eisai Co Ltd Details
AD-35 AD-35 Phase 2 Clinical Zhejiang Hisun Pharmaceutical Co Ltd Alzheimer Disease Details
Lu-AF-20513 Lu-AF-20513 H. Lundbeck A/S, Otsuka Pharmaceutical Co Ltd Details
Indole-3-propionic acid SHP-22; SHP-622; VP-20629; OX-1; IN-OX1 Intellect Neurosciences Details
SHR-1707 SHR-1707 Phase 1 Clinical Shanghai Hengrui Pharmaceutical Co Ltd Alzheimer Disease Details
UBITh AD immunotherapeutic vaccine (United Biomedical) UB-311 United Biomedical Inc Details
KHK-6640 KHK-6640 Immunas Details
PPI-1019 PPI-1019 Glaxosmithkline Plc Details
ALZ-101 ALZ-101 Phase 1 Clinical Alzinova AB Alzheimer Disease Details
AAB-003 AAB-003; PF-5236812; PF-05236812 Pfizer Pharmaceuticals Ltd (China), Elan Corp Details
Anatabine citrate RCP-006 Clinical Rock Creek, Roskamp Institute Alzheimer Disease; Inflammation Details
CAD-106 CAD-106 Kuros Biosciences, Novartis Pharma Ag Details
SAR-228810 SAR-228810 Sanofi Details
Aftobetin ANCA-11 Cognoptix Inc, University Of California San Diego Details
MRZ-99030 EG-030; GAL-101; MRZ-99030 Tel Aviv University Trust Details
Crenezumab R-7412; RG-7412; RO-5490245; MABT-5102-A Phase 2 Clinical Ac Immune Sa, Genentech Inc Alzheimer Disease Details
L-clausenamide Phase 2 Clinical Guangzhou Nuohao Pharmaceutical Technology Co Ltd, Fuan Pharmaceutical (Group) Co Ltd, Institue Of Materia Medica Chinese Academy Of Medical Science, Qingdao Huanghai Pharmaceutical Co Ltd Cognitive Dysfunction; Dementia; Memory Disorders Details
18F-92 18F-92 Phase 2 Clinical First Affiliated Hospital Of Fujian Medical University Alzheimer Disease Details
Edonerpic T-817 MA Phase 2 Clinical Toyama Chemical Co Ltd, Fujifilm Group Alzheimer Disease; Cognitive Dysfunction; Hepatic Insufficiency Details
Inositol/Vitamin B1/Vitamin B2 Details
Procaine Hydrochloride/Vitamin B6/Inositol Details
Birtamimab NEOD-001 Phase 3 Clinical Prothena Immunoglobulin Light-chain Amyloidosis; Amyloidosis Details
123I-ABC-577 123I-ABC-577 Clinical Nihon Medi-Physics Co Ltd Diagnostic agents Details
Valiltramiprosate NRM-8499; ALZ-801; BLU-8499 Phase 3 Clinical Alzheon Inc Alzheimer Disease Details
Buntanetap ANVS-405; ANVS-401 Phase 3 Clinical Raptor Pharmaceutical Down Syndrome; Chronic Traumatic Encephalopathy; Alzheimer Disease; Cognitive Dysfunction; Parkinson Disease; Frontotemporal Dementia Details
BEY-2153 BEY-2153 Phase 1 Clinical Beyondbio Inc Alzheimer Disease Details
Tarenflurbil spraygel (MIKA Pharma) Clinical Galen Ltd, Mika Pharma Gmbh Pain; Arthritis, Rheumatoid; Skin Diseases; Inflammation; Dermatitis, Atopic Details
ABvac-40 ABvac-40 Phase 2 Clinical Araclon Biotech Sl Alzheimer Disease; Cognitive Dysfunction Details
PRI-002 RD-2; PRI-002 Phase 1 Clinical Priavoid Cognitive Dysfunction; Alzheimer Disease Details
ALN-APP Phase 1 Clinical Sirna Therapeutics Inc Cerebral Amyloid Angiopathy; Spinocerebellar Degenerations; Alzheimer Disease; Neurodegenerative Diseases Details
Solanezumab LY-2062430 Phase 3 Clinical Eli Lilly And Company Alzheimer Disease; Dementia; Cognition Disorders Details
LY-3372993 LY-3372993 Phase 3 Clinical Eli Lilly And Company Alzheimer Disease Details
ACU-193 ACU-193; ACU193 Phase 1 Clinical Acumen Pharmaceuticals Inc Alzheimer Disease Details
Gantenerumab MAb-31; R-1450; RG-1450; R-04909832 Phase 3 Clinical Chugai Pharmaceutical Co Ltd Dementia; Alzheimer Disease Details
AMDX-2011P AMDX-2011P; AMDX2011P Phase 1 Clinical Amydis Inc Parkinson Disease; Amyotrophic Lateral Sclerosis Details
CT-1812 CT-1812; SV-119 Phase 2 Clinical Cogrx Alzheimer Disease; Cognitive Dysfunction; Lewy Body Disease Details
Pittsburgh Compound B [11C]PIB; [11C]6-OH-BTA-1; 11C-PIB Phase 2 Clinical The University Of Utah, University Of Pittsburgh, Ge Healthcare, Uppsala Universitet Ovarian Neoplasms; Brain Concussion; Breast Neoplasms; Parkinson Disease; Alzheimer Disease; Alcoholism; Dementia Details

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