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CD98

概要

Name:L-type amino acid transporter 1
Target Synonym:D16S469E,Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 5,LAT1,SLC7A5,Y+ System Cationic Amino Acid Transporter,4F2LC,4F2 LC,Large Neutral Amino Acid-Transporter 1,Large Neutral Amino Acids Transporter Small Subunit 1,Solute Carrier Family 7 Member 5,HLAT1,CD98LC,CD98,Sodium-Independent Neutral Amino Acid Transporter LAT1,L-Type Amino Acid Transporter 1,4F2 Light Chain,E16,Solute Carrier Family 7 (Amino Acid Transporter Light Chain, L System), Member 5,MPE16,Integra
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:7
Lastest Research Phase:Phase 2 Clinical

製品リスト製品比較と製品注文

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製造番号 種類 製品説明 構造 純度 特徴
CD8-HF248 Human FITC-Labeled Human CD98 Protein, His Tag
CD8-HF248-structure
CD8-HF248-sds
CD8-H5247 Human Human CD98 Protein, His Tag (MALS verified)
CD8-H5247-structure
CD8-H5247-sds
ACRO Quality

生物活性データの一部

CD8-H5247-MALS-HPLC
CD98 MALS images

The purity of Human CD98, His Tag (Cat. No. CD8-H5247) is more than 90% and the molecular weight of this protein is around 50-70 kDa verified by SEC-MALS.

CD8-H5247-ELISA
 CD98 ELISA

Immobilized Human CD98, His Tag (Cat. No. CD8-H5247) at 1 μg/mL (100 μL/well) can bind CD98 Recombinant Rabbit Monoclonal Antibody with a linear range of 0.2-2 ng/mL (QC tested).

Synonym Name

SLC3A2,CD98,4F2,4F2HC,4T2HC,CD98HC,MDU1,NACAE

Background

CD antigen CD98 is also known as 4F2 cell-surface antigen heavy chain (4F2hc), 4F2 heavy chain antigen, Solute carrier family 3 member 2 (SLC3A2), Lymphocyte activation antigen 4F2 large subunit, is a single-pass type I I membrane protein which belongs to the SLC3A transporter family.. SLC3A2 / CD98 is expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. SLC3A2 / CD98 is required for the function of light chain amino-acid transporters and also involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. CD98 involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A5 or SLC7A8, CD98 involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
R-OKY-034F R-OKY-034F Phase 2 Clinical Osaka University, Japan Agency For Medical Research And Development Pancreatic Neoplasms Details
[18F]AA-7 [18F]AA-7 Clinical Osaka City University, Institute Physical Chemical Research (Riken), Nagase Medicals Glioma Details
QBS-10072-S QBS10072S; QBS72S; QBS-72-S; QBS-10072-S Phase 2 Clinical Novotech (Australia) Pty Ltd Breast Neoplasms; Brain metastases Details
IGN-523 IGN-523 Igenica Details
Nanvuranlat JPH-203SBECD; JPH-203; KYT-0353 Phase 2 Clinical J-Pharma Biliary Tract Neoplasms Details
131I-ACD-101 131I-ACD-101; 131I-IPA; 131I-TX-101 Phase 2 Clinical Telix Pharmaceuticals Ltd Neoplasms; Glioblastoma; Breast Neoplasms Details
O-18F-fluoroethyl-L-tyrosine 18F-FET; FET-[18F]; TLX101-CDx; TLX-101-CDx Phase 2 Clinical Advanced Imaging Projects Breast Neoplasms; Sarcoma; Glioma; Lymphoma Details
NBQ72S NBQ72S Phase 1 Clinical Solid tumours; Brain Neoplasms Details

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