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Your Position: ホーム > ASGR1

ASGR1

概要

Name:Asialoglycoprotein receptor 1
Target Synonym:C-type lectin domain family 4 member H1,HL-1,Hepatic lectin H1,ASGPR 1,ASGR1,Asialoglycoprotein Receptor 1,CLEC4H1,ASGP-R 1,ASGPR1,ASGPR
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

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製造番号 種類 製品説明 構造 純度 特徴
AS1-M5243 Mouse Mouse ASGR1 Protein, His Tag (MALS verified)
AS1-M5243-structure
AS1-M5243-sds
AS1-M5255 Mouse Mouse ASGR1 Protein, Fc Tag (MALS & SPR verified)
AS1-M5255-structure
AS1-M5255-sds
AS1-C5253 Cynomolgus Cynomolgus ASGR1 Protein, Fc Tag
AS1-C5253-structure
AS1-C5253-sds
AS1-C5243 Cynomolgus Cynomolgus ASGR1 Protein, His Tag
AS1-C5243-structure
AS1-C5243-sds
AS1-R5253 Rat Rat ASGR1 / ASGPR1 Protein, Fc Tag
AS1-R5253-structure
AS1-R5253-sds
CHEK-ATP080 Human HEK293/Human ASGR1 Stable Cell Line
MBS-K055 Human Human ASGR1-coupled Magnetic Beads
AS1-H5243 Human Human ASGR1 / ASGPR1 Protein, His Tag (MALS & SPR verified)
AS1-H5243-structure
AS1-H5243-sds
GS1-H82Q3 Human Biotinylated Human ASGR1 / ASGPR1 Protein, His,Avitag™
GS1-H82Q3-structure
GS1-H82Q3-sds
AS1-H5253 Human Human ASGR1 / ASGPR1 Protein, Fc Tag (MALS verified)
AS1-H5253-structure
AS1-H5253-sds
ACRO Quality

生物活性データの一部

CHEK-ATP080-Cell-based assay
ASGR1 FACS

Fig. FACS analysis of ASGR1 on HEK293/Human ASGR1 Stable Cell Line.
FACS assay shows that Anti-ASGR1 Antibody can bind to HEK293/Human ASGR1 Stable Cell Line. HEK293/Human ASGR1 Stable Cell Line was red line, Negative control HEK293 cells was grey line (QC tested).

Protocol
AS1-M5255-SPR
ASGR1 SPR

SARS-CoV-2 S1 protein NTD, His Tag (Cat. No. S1D-C52H6) immobilized on CM5 Chip can bind Mouse ASGR1 Protein, Fc Tag (Cat. AS1-M5255) with an affinity constant of 1.16 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
AS1-H5243-SPR
ASGR1 SPR

Human ASGR1 / ASGPR1 Protein, His Tag (Cat. No. AS1-H5243) immobilized on CM5 Chip can bind SARS-CoV-2 S1 protein, His Tag with an affinity constant of 50.2 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol

Synonym Name

ASGP-R 1, ASGPR 1, C-type lectin domain family 4 member H1, Hepatic lectin H1, HL-1

Background

ASGPR, a transmembrane C-type lectin, recognizes a wide variety of ligands that contain either terminal galactose (Gal) or N-acetylgalactosamine (GalNAc) residues and has been identified as a highly selective receptor on hepatocytes. The ASGR is composed of both a major (ASGR1) and minor subunit (ASGR2). ASGR1 has been shown to be efficiently targeted to the plasma membrane and to undergo constitutive endocytosis and recycling and found mainly expressed in the human liver.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
AMG-529 AMG529; AMG-529 Amgen Inc Details

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