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JAK1

概要

Name:Tyrosine-protein kinase JAK1
Target Synonym:JAK1B,Tyrosine-protein kinase JAK1,JAK1,Janus Kinase 1,JAK1A,EC 2.7.10.2,JAK-1,JTK3,EC:2.7.10.2,EC 2.7.10
Number of Launched Drugs:8
Number of Drugs in Clinical Trials:45
Lastest Research Phase:Approved

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製造番号 種類 製品説明 構造 純度 特徴
JA1-H5547 Human Human JAK1 Protein, His Tag
JA1-H5547-structure
JA1-H5547-sds
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Synonym Name

JAK1,JAK-1,JAK1A,JAK1B,Jak1

Background

JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (?c) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body

Clinical and Translational Updates

公開薬物情報

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Filgotinib Maleate G-146034-101; GS-6034; G-146034; GLPG-0634 Approved Galapagos Nv Jyseleca Japan Colitis, Ulcerative Gilead Sciences Kk 2020-09-24 Non-radiographic axial spondyloarthritis; Inflammatory Bowel Diseases; Arthritis, Rheumatoid; Lupus Erythematosus, Cutaneous; Spondylitis, Ankylosing; Sjogren's Syndrome; Kidney Diseases; Lupus Nephritis; Glomerulonephritis, Membranous; Colitis, Ulcerative; Arthritis, Psoriatic; Uveitis; Crohn Disease Details
Abrocitinib PF-4965842; PF-04965842 Approved Pfizer Inc 希必可, Cibinqo Mainland China Dermatitis, Atopic Pfizer Investment Co Ltd 2021-09-09 Pruritus; Kidney Diseases; Dermatitis; Skin Diseases; Immune System Diseases; Skin Diseases, Eczematous; Genetic Diseases, Inborn; Psoriasis; Food Hypersensitivity; Hepatic Insufficiency; Prurigo; Hypersensitivity, Immediate; Hypersensitivity; Skin Diseases, Genetic; Eczema; Dermatitis, Atopic Details
Peficitinib ASP-015K; JNJ-54781532 Approved Astellas Pharma Inc Smyraf Japan Arthritis, Rheumatoid Astellas Pharma Inc 2019-03-29 Arthritis, Rheumatoid; Psoriasis; Colitis, Ulcerative Details
Upadacitinib ABT-494 Approved Abbvie Inc Rinvoq Japan Colitis, Ulcerative Abbvie Gk 2019-08-16 Non-radiographic axial spondyloarthritis; Giant Cell Arteritis; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Spondylarthritis; Arthritis, Juvenile; Lupus Erythematosus, Systemic; Takayasu Arteritis; Arthritis, Psoriatic; Colitis, Ulcerative; Hidradenitis Suppurativa; Dermatitis, Atopic; Crohn Disease; Vitiligo Details
Baricitinib LY-3009104; INCB-028050 Approved Incyte Corp 艾乐明, Olumiant United States Alopecia Areata Eli Lilly And Company 2017-02-13 Conjunctivitis; Dermatitis, Atopic; Renal Insufficiency, Chronic; Wounds and Injuries; Skin Diseases, Papulosquamous; Skin Ulcer; Hepatic Insufficiency; Diabetic Nephropathies; Severe Acute Respiratory Syndrome; Pyoderma; Coronavirus Infections; Psoriasis; Lupus Erythematosus, Systemic; Polymyalgia Rheumatica; Lupus Nephritis; Infections; Liver Diseases; Skin Diseases; Arthritis, Juvenile; Pemphigoid, Benign Mucous Membrane; Graft vs Host Disease; Coronavirus Disease 2019 (COVID-19); Arthritis, Rheumatoid; Dermatomyositis; Pyoderma Gangrenosum; Myositis; Alopecia Areata; HIV Infections; Liver Cirrhosis, Biliary; Diabetes Mellitus, Type 1 Details
Ruxolitinib Phosphate INCB-018424; INC-424; INCB-424; INCB-18424 Approved Incyte Corp Jakafi, Jakavi, OPZELURA United States Vitiligo Incyte Corp 2011-11-16 Coronavirus Infections; Lymphoma; Hidradenitis Suppurativa; Lichen Planus; Hyperplasia; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; Hepatomegaly; Leukemia, Myeloid, Chronic-Phase; Primary Myelofibrosis; Carcinoma, Squamous Cell; Carcinoma, Intraductal, Noninfiltrating; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Breast Neoplasms; Leukemia, Neutrophilic, Chronic; Ectodermal Dysplasia; Psoriasis; Prostatic Neoplasms; Thrombocytosis; Lymphohistiocytosis, Hemophagocytic; Cachexia; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Lichen Sclerosus et Atrophicus; Splenomegaly; Thrombocythemia, Essential; Vitiligo; Dermatitis, Atopic; Leukemia, Lymphocytic, Chronic, B-Cell; Carcinoma, Non-Small-Cell Lung; Leukemia, T-Cell; Eczema; Leukemia, Large Granular Lymphocytic; Myelodysplastic-Myeloproliferative Diseases; Cytokine Release Syndrome; Arthritis, Rheumatoid; Leukemia, Myelomonocytic, Chronic; Graft vs Host Disease; Myeloproliferative Disorders; Lupus Erythematosus, Discoid; Alopecia Areata; Squamou Details
Tofacitinib Citrate CP-690550-10; CKD-374; Tasocitinib; BI-764524; CP-690550; AC-1101; IMG 003; SSS-32 Approved Pfizer Inc Jakvinus, Xeljanz United States, EU Spondylitis, Ankylosing Pfizer Inc, Pfizer Europe Ma Eeig 2012-11-06 Inflammation; Lung Diseases, Interstitial; Lung Diseases; Dry Eye Syndromes; Granuloma Annulare; Lupus Erythematosus, Systemic; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Sarcoidosis, Pulmonary; Hepatic Insufficiency; Arthritis, Juvenile; Granulomatous Disease, Chronic; Uveitis; Hidradenitis Suppurativa; Dermatitis, Atopic; Crohn Disease; Diabetic Retinopathy; Vitiligo; Eczema; Plaque psoriasis; Arthritis, Rheumatoid; Alopecia; Keratoconjunctivitis Sicca; Dermatomyositis; Lupus Erythematosus, Discoid; Gastrointestinal Diseases; Depression; Alopecia Areata; Scleritis; Sacroiliitis; Down Syndrome; Rejection of renal transplantation; Glioblastoma; Spondylitis, Ankylosing; Scleroderma, Systemic; Lupus Erythematosus, Cutaneous; Sarcoidosis; Sjogren's Syndrome; Coronavirus Disease 2019 (COVID-19); Kidney Diseases; Spondylitis Details

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
LBG-1600M Phase 1 Clinical Suzhou Longbotai Pharmaceutical Co Ltd Dermatitis, Atopic Details
TT-00420/Atezolizumab Phase 1 Clinical Gastrointestinal Neoplasms Details
NIP-046 NIP-046 Phase 1 Clinical Arthritis, Rheumatoid Details
WXFL-10203614 WXFL-10203614 Phase 2 Clinical Wuxi Fuxin Pharmaceutical Research And Development Co Ltd, Wuxi Apptec Co Ltd Arthritis, Rheumatoid Details
H-018 H018; H-018 Phase 1 Clinical Jiangsu Carephar Pharmaceutical Co Ltd, Nanjing Shenzhou Jiamei Pharmaceutical Co Ltd Arthritis, Rheumatoid Details
ATI-501 A-201; ATI-501; ATI-50001 Rigel Pharmaceuticals Inc Details
MAX-40070 MAX-40070 Phase 1 Clinical Maxinovel Pty Ltd Alopecia Areata Details
ATI-502 A-301; ATI-502; ATI-50002 Rigel Pharmaceuticals Inc Details
PF-6263276 PF-6263276; PF-06263276 Pfizer Pharmaceuticals Ltd (China) Details
AZD-1480 AZD-1480 Astrazeneca Pharmaceutical Co Ltd Details
Elsubrutinib/Upadacitinib ABBV-599 Phase 1 Clinical Abbvie Inc Lupus Erythematosus, Systemic Details
GLPG-3121 GLPG-3121 Phase 1 Clinical Galapagos Nv Details
CS-12192 CS12192 Phase 1 Clinical Shenzhen Chipscreen Biosciences Co Ltd Enteritis; Alopecia Areata; Autoimmune Diseases; Graft vs Host Disease; Multiple Sclerosis; Lupus Erythematosus, Systemic; Dermatitis, Atopic Details
PG-011 PG-011 Phase 2 Clinical Prime Gene Therapeutics Co Ltd Epidermolysis Bullosa; Rhinitis, Allergic; Prurigo; Eye Diseases; Dermatitis, Atopic Details
AQ-280 AQ-280 Phase 1 Clinical Aqilion AB Eosinophilic Esophagitis Details
Tinengotinib TT-00420 Phase 2 Clinical TransThera Sciences (Nanjing) Inc Solid tumours; Biliary Tract Neoplasms; Stomach Neoplasms; Small Cell Lung Carcinoma; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Cholangiocarcinoma; Breast Neoplasms; Prostatic Neoplasms; Sarcoma; Thyroid Neoplasms; Gallbladder Neoplasms Details
TLL-018 TLL-018 Phase 2 Clinical Tll Pharmaceutical Llc Chronic Urticaria; Arthritis, Rheumatoid; Psoriasis; Colitis, Ulcerative; Urticaria Details
Fingolimod/Tofacitinib FMX-114 Phase 2 Clinical Vyne Therapeutics Inc Dermatitis, Atopic Details
LNK-01002 LNK01002 Phase 1 Clinical Lynk Pharmaceutical (Hangzhou) Co Ltd Hematologic Neoplasms; Primary Myelofibrosis; Leukemia, Myeloid, Acute Details
WXSH-0150 WXSH-0150; TUL-01101 Phase 1 Clinical Zhuhai United Laboratories Co Ltd Arthritis, Rheumatoid; Dermatitis, Atopic Details
VC-005 VC-005 Phase 1 Clinical Jiangsu Vcare Pharmatech Co Ltd Inflammatory Bowel Diseases; Joint Diseases; Colitis, Ulcerative; Crohn Disease; Vitiligo; Dermatitis, Atopic Details
QY201 QY-201; QY201 Phase 2 Clinical E-nitiate Biopharmaceuticals (Hangzhou) Co Ltd Alopecia Areata; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Dermatitis, Atopic Details
Golidocitinib NC-0322; AZD-4205; DZD-4205 Phase 2 Clinical Astrazeneca Plc, Dizal (Jiangsu) Pharmaceutical Co Ltd Lymphoma, T-Cell, Peripheral; Lymphoma, T-Cell, Cutaneous; Carcinoma, Non-Small-Cell Lung Details
Ivarmacitinib sulfate SHR-0302; ARQ-252 Phase 3 Clinical Jiangsu Hengrui Medicine Co Ltd Non-radiographic axial spondyloarthritis; Alopecia Areata; Spondylitis, Ankylosing; Spondylarthritis; Arthritis, Rheumatoid; Colitis, Ulcerative; Hepatic Insufficiency; Arthritis, Psoriatic; Eczema; Vitiligo; Dermatitis, Atopic; Crohn Disease Details
Deuterated Ruxolitinib CTP-543 Phase 3 Clinical Concert Alopecia Areata; Kidney Diseases; Hepatic Insufficiency Details
Brepocitinib PF-06700841-15; PF-6700841; PF-841; PF-06700841 Phase 3 Clinical Pfizer Inc Alopecia; Alopecia Areata; Dermatomyositis; Kidney Diseases; Lupus Erythematosus, Systemic; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Hidradenitis Suppurativa; Dermatitis, Atopic; Vitiligo; Crohn Disease Details
Itacitinib INCB-039110-adipate; INCB-39110; INCB-039110; IBI-377 Phase 3 Clinical Incyte Corp Lymphoma; Psoriasis; Hemic and Lymphatic Diseases; Thrombocytosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Breast Neoplasms; Sarcoma; Colitis, Ulcerative; Primary Myelofibrosis; Asthma; Colorectal Neoplasms; Lymphohistiocytosis, Hemophagocytic; Sarcoma, Synovial; Lung Neoplasms; Lymphoma, Non-Hodgkin; Leukemia, Myeloid, Acute; Endometrial Neoplasms; Myelodysplastic-Myeloproliferative Diseases; Neoplasm Metastasis; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Liposarcoma, Myxoid; Melanoma; Carcinoma, Renal Cell; Cytokine Release Syndrome; Leukemia; Lymphoma, B-Cell; Bronchiolitis Obliterans; Solid tumours; Head and Neck Neoplasms; Chondrosarcoma; Leiomyosarcoma; Polycythemia Vera; Pruritus; Hematologic Neoplasms; Arthritis, Rheumatoid; Graft vs Host Disease; Hodgkin Disease; Neoplasms; Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic; Myeloproliferative Disorders; Carcinoma, Transitional Cell; Pancreatic Neoplasms; Liposarcoma Details
LW-402 LW-402 Phase 2 Clinical Shanghai Longwood Biopharmaceuticals Co Ltd Arthritis, Rheumatoid; Dermatitis, Atopic Details
Povorcitinib INCB-54707; INCB54707; INCB054707; INCB-054707 Phase 3 Clinical Incyte Corp Renal Insufficiency; Kidney Diseases; Prurigo; Hidradenitis Suppurativa; Vitiligo Details
FZJ-003 FZJ-003 Phase 1 Clinical Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd Arthritis, Rheumatoid; Dermatitis, Atopic Details
LNK-01001 LNK01001; LNK-01001 Phase 2 Clinical Lynk Pharmaceutical (Hangzhou) Co Ltd Spondylitis, Ankylosing; Arthritis, Rheumatoid; Dermatitis, Atopic Details
ATI-1777 Phase 2 Clinical Aclaris Therapeutics Inc Dermatitis, Atopic Details

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