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Your Position: ホーム > B7-H5

B7-H5

概要

Name:V-domain Ig suppressor of T-cell activation
Target Synonym:Dies1,VSIR,V-Set Domain-Containing Immunoregulatory Receptor,DD1alpha,B7-H5,PD-1H,B7H5,GI24,Stress-induced secreted protein-1,PP2135,SISP1,UNQ730/PRO1412,V-type immunoglobulin domain-containing suppressor of T-cell activation,V-Set Immunoregulatory Receptor,V-Domain Ig Suppressor Of T Cell Activation,PDCD1 Homolog,C10orf54,Sisp-1,VISTA,Chromosome 10 Open Reading Frame 54,Stress Induced Secreted Protein 1,Platelet Receptor Gi24,Death Domain1alpha
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 2 Clinical

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製造番号 種類 製品説明 構造 純度 特徴
B75-H5258 Human Human B7-H5 / Gi24 / VISTA Protein, Mouse IgG2a Fc Tag, low endotoxin
B75-H5258-structure
B75-H5258-sds
B75-H82F3 Human Biotinylated Human B7-H5 / Gi24 / VISTA Protein, Fc,Avitag™
B75-H82F3-structure
B75-H82F3-sds
B75-M52H7 Mouse Mouse B7-H5 / Gi24 / VISTA Protein, His Tag
B75-M52H7-structure
B75-M52H7-sds
B75-C5220 Rhesus macaque Rhesus macaque B7-H5 / Gi24 / VISTA Protein, His Tag
B75-C5220-structure
B75-C5220-sds
B75-H82E1 Human Biotinylated Human B7-H5 / Gi24 / VISTA Protein, Avitag™,His Tag
B75-H82E1-structure
B75-H82E1-sds
B75-H5259 Human Human B7-H5 / Gi24 / VISTA Protein, Fc Tag
B75-H5259-structure
B75-H5259-sds
B75-H52H0 Human Human B7-H5 / Gi24 / VISTA Protein, His Tag (MALS verified)
B75-H52H0-structure
B75-H52H0-sds
ACRO Quality

生物活性データの一部

B75-H5258-SPR
B7-H5 SPR

Human B7-H5 Protein, Mouse IgG2a Fc Tag (Cat. No. B75-H5258) Captured on CM5 chip via anti-mouse antibodies surface can bind Human VSIG3, Fc Tag (Cat. No. VS3-H5258) with an affinity constant of 8.87 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol
B75-H5259-SPR
B7-H5 SPR

Human PSGL-1, His Tag (Cat. No. PS1-H52H9) immobilized on CM5 Chip can bind Human B7-H5, Fc Tag (Cat. No. B75-H5259) with an affinity constant of 0.213 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol

Synonym Name

B7-H5,SISP1,Gi24,VISTA

Background

Platelet receptor Gi24, also known as B7-H5 and stress-induced secreted protein-1 (Sisp-1), is a protein that in humans is encoded by the C10orf54 gene, which contains 1 Ig-like (immunoglobulin-like) domain. As for C10orf54 gene, C10orf54 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state on ESCs. Human C10orf54 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
W-0180 W-0180 Phase 1 Clinical France Pierre Fabre Medicament Shanghai Representative Office Solid tumours Details
Onvatilimab CI-8993; JNJ-61610588 Phase 1 Clinical Janssen Global Services Llc, Immunext Inc Solid tumours; Neoplasms Details
HMBD-002 HMBD-002 Phase 1 Clinical Hummingbird Bioscience Solid tumours; Triple Negative Breast Neoplasms; Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis Details
KVA-12123 KVA-12.1; KVA-12123 Phase 2 Clinical Kineta Inc Pancreatic Neoplasms; Melanoma; Thyroid Neoplasms; Uterine Neoplasms; Lung Neoplasms; Colorectal Neoplasms; Breast Neoplasms; Sarcoma; Prostatic Neoplasms; Head and Neck Neoplasms; Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Carcinoma; Ovarian Neoplasms; Solid tumours; Kidney Neoplasms Details

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