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Your Position: ホーム > Protein > GITR Ligand > GIL-M526x

Mouse GITR Ligand / TNFSF18 Protein, Fc Tag

  • Synonym
    TNFSF18,AITRL,TL6,hGITRL,GITR Ligand
  • Source
    Mouse GITR Ligand, Fc Tag(GIL-M526x) is expressed from human 293 cells (HEK293). It contains AA Thr 47 - Ser 173 (Accession # AAO89011).
  • Molecular Characterization
    GITR Ligand Structure

    This protein carries a human IgG1 Fc tag at the N-terminus.

    The protein has a calculated MW of 41.4 kDa. The protein migrates as 45 kDa under reducing (R) condition, and 80-100 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
GITR Ligand SDS-PAGE

Mouse GITR Ligand, Fc Tag on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

Bioactivity-ELISA
 GITR Ligand ELISA

Immobilized Mouse GITR Protein, His Tag (Cat. No. GIR-M52H3) at 5 μg/mL (100 μL/well) can bind Mouse GITR Ligand, Fc Tag (Cat. No. GIL-M526x) with a linear range of 2-39 ng/mL (QC tested).

  • Background
    Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is also known as Glucocorticoid - induced TNF-related ligand (GITRL or GITR Ligand), Activation - inducible TNF - related ligand (AITRL), which belongs to the tumor necrosis factor family. TNFSF18 is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 / GITRL is up-regulated after stimulation by bacterial lipopolysaccharides (LPS). TNFSF18 Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. TNFSF18 / GITR Ligand is important for interactions between activated T-lymphocytes and endothelial cells. TNFSF18 also mediates activation of NF-kappa-B.
  • Clinical and Translational Updates

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