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Your Position: ホーム > IL-4

IL-4

概要

Name:Interleukin-4
Target Synonym:MGC79402,B-cell stimulatory factor 1,Lymphocyte stimulatory factor 1,IL4,Interleukin 4,B_cell Stimulatory Factor 1,B Cell Growth Factor 1,Binetrakin,Pitrakinra,BSF-1,IL-4,Interleukin 4 Variant 2,BCGF-1,BCGF1,BSF1,Interleukin-4
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:9
Lastest Research Phase:Approved

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製造番号 種類 製品説明 構造 純度 特徴
IL4-PFS269 Mouse PE-Labeled Monoclonal Anti-human IL-4 Antibody, IgG1 (0.03% Proclin)
FMBc005-02 0 Anti-mouse IL-4 Antibody-coupled APC-beads-B05
FABr015-B Rat Biotinylated Monoclonal Anti-Mouse IL-4 Antibody, Rat IgG1 (AS542)
RAS-SP010 Mouse Mouse IL-4 ELISPOT Kit
GMP-L04H26 Human GMP Human IL-4 Protein
GMP-L04H26-structure
GMP-L04H26-sds
IL4-H5253 Human Human IL-4 Protein, Fc Tag (MALS verified)
IL4-H5253-structure
IL4-H5253-sds
CRS-B003 Human ClinMax™ Human IL-4 ELISA Kit
EP-132 Human IL-4 [Biotinylated] : IL-4Rα Inhibitor Screening ELISA Kit
CRS-A004 Human resDetect™ Human Interleukin-4 (IL-4) ELISA Kit (Residue Testing)
IL4-H52H9 Human Human IL-4 Protein, His Tag (MALS verified)
IL4-H52H9-structure
IL4-H52H9-sds
IL4-C5259 Cynomolgus Cynomolgus IL-4 Protein, Fc Tag (MALS verified)
IL4-C5259-structure
IL4-C5259-sds
IL4-M52H5 Mouse Mouse IL-4 Protein, His Tag
IL4-M52H5-structure
IL4-M52H5-sds
IL4-H82E0 Human Biotinylated Human IL-4 Protein, Avitag™,His Tag (MALS verified)
IL4-H82E0-structure
IL4-H82E0-sds
IL4-H4218 Human Human IL-4 Protein, premium grade
IL4-H4218-structure
IL4-H4218-sds
IL4-H4218-hplc
ACRO Quality

生物活性データの一部

GMP-L04H26-Cell-based assay
IL-4 CELL

GMP Human IL-4 Protein (Cat. No. GMP-L04H26) stimulates proliferation of TF-1 human erythroleukemic cell line. The specific activity of GMP Human IL-4 Protein is > 1.20×10^7 IU/mg, which is calibrated against human IL-4 WHO International Standard (NIBSC code: 88/656) (QC tested).

Protocol
IL4-H82E0-Cell-based assay
IL-4 CELL

Biotinylated Human IL-4, Avitag,His Tag (Cat. No. IL4-H82E0) stimulates the proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is 1.19-2.64 ng/mL (Routinely tested).

Protocol
IL4-H52H9-ELISA
IL-4 ELISA

Immobilized Human IL-4, His Tag (Cat. No. IL4-H52H9) at 5 μg/mL (100 μL/well) can bind Human IL-4 R alpha, Fc Tag (Cat. No. ILR-H5253) with a linear range of 0.5-16 ng/mL (QC tested).

Protocol
IL4-H5253-MALS-HPLC
IL-4 MALS images

The purity of Human IL-4 Protein, Fc Tag (Cat. No. IL4-H5253) is more than 90% and the molecular weight of this protein is around 90-110 kDa verified by SEC-MALS.

カスタマーレビュー

Synonym Name

IL4,BCGF1,BSF1

Background

Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
Dectrekumab/VAK-694 QBX-258 Phase 2 Clinical Novartis Pharma Ag Lymphedema; Asthma Details
OCH-NCNP1 OCH-NCNP1 Phase 2 Clinical Keio University Multiple Sclerosis; Crohn Disease Details
AIR-645 AIR-645; ISIS-369645 Ionis Pharmaceuticals Inc Details
Romilkimab SUB-33159; SAR-156597 Sanofi Details
GSK-2434735 GSK-2434735 Glaxosmithkline Plc Details
VAK-694 VAK-694; NVP-VAK-694 Novartis Pharma Ag Details
Berdazimer sodium NVN1000-SB206; MAP3-NONOate - SB-206; SB-019; NVN-1000-SB-206-Novan; SB-206 Phase 3 Clinical Novan Inc Acne Vulgaris; Tinea Pedis; Psoriasis; Molluscum Contagiosum; Condylomata Acuminata; Dermatitis, Atopic Details
AUP1602-C AUP-16; AUP1602-C Phase 2 Clinical Aurealis Diabetic Foot Details

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