ログイン 会員登録
icon_bulk_order一括注文 Acrobiosystems for English
Promotion
Recombinantタンパク質s ClearClear history
Recombinantタンパク質s CloseClose
Browse Products By Molecule Name a-zA-Z
TL1A Hot |GMP IL-2 Hot |Omicron specific antibody Hot |Claudin 18.2 |Cadherin-17
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
phone
Your Position: ホーム > GPRC5D

GPRC5D

概要

Name:G-protein coupled receptor family C group 5member D
Target Synonym:G Protein-Coupled Receptor Class C Group 5 Member D,G-Protein Coupled Receptor Family C Group 5 Member D,G Protein-Coupled Receptor, Class C, Group 5, Member D,G Protein-Coupled Receptor, Family C, Group 5, Member D,GPRC5D,Orphan G-Protein Coupled Receptor
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:19
Lastest Research Phase:Approved

Antibody Licensing

Project Name Project Stage Molecule Type Host Species Therapeutic Area Indications
GPRC5D VHH - 01 PCC Hematological Malignancy Multiple myeloma

製品リスト製品比較と製品注文

製品> フィルター結果
製品仕様別：
製品カテゴリー別：
種類別：
タグ別：
コンジュゲート：
製造番号 種類 製品説明 構造 純度 特徴
GPD-M52D3 Mouse Mouse GPRC5D Protein, Flag,His Tag (Detergent)
GPD-M52D3-structure
GPD-M52D3-sds
GPD-M52P3 Mouse Mouse GPRC5D Full Length Protein (VLP)
GPD-HF2G5 Human Fluorescent Human GPRC5D Full Length Protein (VLP)
GPD-H52P7 Human Human GPRC5D Full Length Protein (VLP)
CCHO-STP078 Human CHO/Human GPRC5D Stable Cell Line
GPD-HF2D7 Human FITC-Labeled Human GPRC5D Protein, Flag,His Tag (Nanodisc)
GPD-HF2D7-structure
GPD-HF2D7-sds
GPD-C52D3 Cynomolgus Cynomolgus GPRC5D Protein, Flag,His Tag (Detergent) (SPR verified)
GPD-C52D3-structure
GPD-C52D3-sds
CHEK-STP042 Human HEK293/Human GPRC5D Stable Cell Line
GPD-C82D4 Cynomolgus Cynomolgus GPRC5D Protein, Flag,His Tag (Nanodisc)
GPD-C82D4-structure
GPD-C82D4-sds
GPD-H82D6 Human Biotinylated Human GPRC5D Protein, His,Avitag™&Flag Tag (Detergent)
GPD-H82D6-structure
GPD-H82D6-sds
GPD-H82D4 Human Biotinylated Human GPRC5D Protein, His,Avitag™&Flag Tag (Nanodisc)
GPD-H82D4-structure
GPD-H82D4-sds
GPD-H52D3 Human Human GPRC5D Protein, Flag,His Tag (Detergent)
GPD-H52D3-structure
GPD-H52D3-sds
GPD-H52D4 Human Human GPRC5D Protein, Flag,His Tag (Nanodisc)
GPD-H52D4-structure
GPD-H52D4-sds
ACRO Quality

生物活性データの一部

CCHO-STP078-Cell-based assay
GPRC5D FACS

FACS Analysis of CHO/Human GPRC5D Stable Cell Line.

FACS assay shows that Anti-GPRC5D antibody can bind to CHO/Human GPRC5D Stable Cell Line (Fig. B), and non-transfected CHO cells were used as a negative control (Fig. A). PE signal was used to evaluate the binding activity (QC tested).

Protocol
GPD-HF2D7-SPR
GPRC5D SPR

Anti-GPRC5D Antibody, Human IgG4 captured on Protein A Chip can bind FITC-Labeled Human GPRC5D Protein, Flag,His Tag (Cat. No. GPD-HF2D7) with an affinity constant of 9.29 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
GPD-C52D3-SPR
GPRC5D SPR

Anti-GPRC5D Antibody immobilized on CM5 Chip can bind Cynomolgus GPRC5D, Flag,His Tag (Cat. No. GPD-C52D3) with an affinity constant of 0.122 μM as determined in a SPR assay (Biacore T200) (QC tested).

Protocol

Synonym Name

GPRC5D

Background

G-protein coupled receptor family C group 5 member D (GPRC5D) is a retinoic acid-inducible 40 kDa protein with seven transmembrane segments and a short N terminal extracellular region. Widely expressed in the peripheral system. Expression pattern is high in pancreas, medium in kidney, small intestine, spleen and testis, low in lung, colon, leukocyte, prostate and thymus and not detectable in brain, heart, liver, placenta, skeletal muscle and ovary.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
OriC-321 OriC-321; Ori-C-321 Phase 1 Clinical Zhejiang University Multiple Myeloma Details
MCARH-109 Phase 1 Clinical Memorial Sloan Kettering Cancer Center Multiple Myeloma Details
RO-7425781 RO-7425781 Phase 1 Clinical F. Hoffmann-La Roche Ltd Multiple Myeloma Details
CAR-GPRC5D CAR-GPRC5D Phase 1 Clinical Nanjing Iaso Biotherapeutics Co Ltd Leukemia, Plasma Cell; Multiple Myeloma Details
Autologous anti-BCMA/GPRC5D CAR-T cell therapy (Xuzhou Medical University) Phase 2 Clinical Xuzhou Medical University (Xzmu) Multiple Myeloma Details
Ori-CAR-017 OriCAR-017; Ori-CAR-017 Phase 1 Clinical OriCell Therapeutics Co Ltd Multiple Myeloma Details
Talquetamab JNJ-7564; JNJ-64407564 Phase 3 Clinical Janssen Global Services Llc, Genmab A/S Hematologic Neoplasms; Multiple Myeloma Details
LM-305 LM-305 Phase 1 Clinical LaNova Medicines Ltd Multiple Myeloma Details
RG-6234 RG-6234 Phase 1 Clinical F. Hoffmann-La Roche Ltd Multiple Myeloma Details

This web search service is supported by Google Inc.

totopphone
Call us
お問い合わせ
グローバル：+1 800-810-0816(Toll Free)
日本：+(0)81-50-547-99099
Email
メールアドレス
order.jp@acrobiosystems.com
Fax
ファックス
+1 888-377-6111
Address
株式会社アクロバイオシステムズ
〒157-0066
東京都世田谷区成城1丁目26番9-101号

アクロバイオシステムズの公式アカウント

linkedin twitter facebook youtube

お問い合わせ（半角英文字で入力してください）

Copyright © 2017 ACROBiosystems. All Rights Reserved
Related Links|Privacy Policy|Terms and Conditions|Legal|Sitemap