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Rat NKG2A&CD94 Protein, Mouse IgG2a Fc Tag (MALS verified)

  • Synonym
    NKG2A & CD94
  • Source
    Rat NKG2A&CD94 Protein, Mouse IgG2a Fc Tag(NC4-R5258) is expressed from human 293 cells (HEK293). It contains AA Thr 90 - Asn 231 (NKG2A) & Lys 32 - Thr 179 (CD94) (Accession # O54872-1 (NKG2A) & O35778-1 (CD94)).
    Predicted N-terminus: Thr 90
  • Molecular Characterization

    This protein carries a mouse IgG2a Fc tag at the C-terminus

    The protein has a calculated MW of 61.0 kDa. The protein migrates as 67-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
NKG2A & CD94 SDS-PAGE

Rat NKG2A&CD94 Protein, Mouse IgG2a Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
NKG2A & CD94 MALS images

The purity of Rat NKG2A&CD94 Protein, Mouse IgG2a Fc Tag (Cat. No. NC4-R5258) is more than 90% and the molecular weight of this protein is around 145-160 kDa verified by SEC-MALS.

  • Background
    CD94 plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. NKG2A/CD159a is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors that inhibits innate immune system activation. CD94 pairs with the NKG2 molecule as a heterodimer. The CD94/NKG2 complex, on the surface of natural killer cells interacts with Human Leukocyte Antigen (HLA)-E on target cells.
  • Clinical and Translational Updates

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価格(USD) : 2310.00

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